Cited by 1,132Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell TransplantationMesenchymal stem cell research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

Open access

Vaziri, H, Dragowska, W, Allsopp, R C, Thomas, T E, Harley, C B, Lansdorp, P M·1994·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.91.21.9857PMC PMC44916

Open this paper in CoChat — free account

Abstract

The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of telomeric DNA from the ends of human chromosomes with each somatic cell division eventually reaches a critical point that triggers cellular senescence. We now show that candidate human stem cells with a CD34+CD38lo phenotype that were purified from adult bone marrow have shorter telomeres than cells from fetal liver or umbilical cord blood. We also found that cells produced in cytokine-supplemented cultures of purified precursor cells show a proliferation-associated loss of telomeric DNA. These findings strongly suggest that the proliferative potential of most, if not all, hematopoietic stem cells is limited and decreases with age, a concept that has widespread implications for models of normal and abnormal hematopoiesis as well as gene therapy.

Integrity signals

Registry

Crossref · 10.1073/pnas.91.21.9857

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Self-citation
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Self-citation
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096
Self-citation
Untitled work
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
Morin, G. B. (1989) · Cell · doi:10.1016/0092-8674(89)90035-4 · Cited by 1,495
Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.
Civin, C., Strauss, L. C., Brovall, C., Fackler, M., Schwartz, J. F., & Shaper, J. H. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.1.157 · Cited by 1,200

Show all 41 references

Sorted by citations

Items 301–400 of 1,000

Effects of Telomerase Modulation in Human Hematopoietic Progenitor Cells
Zimmermann, S., Glaser, S., Ketteler, R., Waller, C. F., Klingmüller, U., & Martens, U. M. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-741 · Cited by 75
Structure and function of telomerase
Collins, K. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80013-5 · Cited by 75
Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age
Baerlocher, G. M., Rice, K., Vulto, I. M., & Lansdorp, P. M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00254.x · Cited by 74
Self-citation
Reduced telomere DNA content is correlated with genomic instability and metastasis in invasive human breast carcinoma
Griffith, J. K., Bryant, J. E., Fordyce, C., Gilliland, F. D., Joste, N. E., & Moyzis, R. K. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006128228761 · Cited by 75
Toll-like receptor triggering in cord blood mesenchymal stem cells
van den Berk, L. C. J., Jansen, B., Siebers-Vermeulen, K. G. C., Netea, M. G., Latuhihin, T. E., Bergevoet, S. M., Raymakers, R. A. P., Kögler, G., Figdor, C. G., Adema, G. J., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00653.x · Cited by 74
Telomeres, telomerase, and hematopoietic stem cell biology
Greenwood, M. J., & Lansdorp, P. M. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.07.003 · Cited by 79
Self-citation
Immunosenescence in HIV Pathogenesis
Pommier, J., Gauthier, L., Livartowski, J., Galanaud, P., Boué, F., Dulioust, A., Marcé, D., Ducray, C., Sabatier, L., Lebeau, J., et al. (1997) · Virology · doi:10.1006/viro.1997.8512 · Cited by 74
Telomerase Activity in Melanocytic Lesions
Rudolph, P., Schubert, C., Tamm, S., Heidorn, K., Hauschild, A., Michalska, I., Majewski, S., Krupp, G., Jabłońska, S., & Parwaresch, R. M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65011-0 · Cited by 75
Haemopoietic stem cells
Bellantuono, I. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.10.008 · Cited by 77
Clonal dynamics of haematopoiesis across the human lifespanPreprint
Mitchell, E., Chapman, M. S., Williams, N., Dawson, K. J., Mende, N., Calderbank, E. F., Jung, H., Mitchell, T. J., Coorens, T. H. H., Spencer, D. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.16.456475 · Cited by 74
Human Cord Blood Cells and Myocardial Infarction: Effect of Dose and Route of Administration on Infarct Size
Henning, R. J., Burgos, J. D., Vasko, M., Alvarado, F., Sanberg, C. D., Sanberg, P. R., & Morgan, M. B. (2007) · Cell Transplantation · doi:10.3727/096368907783338299 · Cited by 75
Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology
Nagele, R. G., Velasco, A. Q., Anderson, W. J., McMahon, D. J., Thomson, Z., Fazekas, J., Kitson-Wind, K., & Lee, H. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.2.377 · Cited by 74
Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer
Widschwendter, A., Müller, H. M., Hubalek, M., Wiedemair, A., Fiegl, H., GOEBEL, G., Mueller‐Holzner, E., Marth, C., & Widschwendter, M. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.01.036 · Cited by 70
Predicting 5-fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length: a multivariate analysis
Garg, M. B., Lincz, L. F., Adler, K., Scorgie, F. E., Ackland, S. P., & Sakoff, J. A. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.421 · Cited by 72
Retention of quiescent hematopoietic cells with high proliferative potential during ex vivo stem cell culture
Young, J., Varma, A., DiGiusto, D. L., & Backer, M. (1996) · Blood · doi:10.1182/blood.v87.2.545.bloodjournal872545 · Cited by 72
Umbilical cord blood for allogeneic transplantation in children and adults
Laughlin, M. J. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1702740 · Cited by 70
Cutting Edge: Antigen-Dependent Regulation of Telomerase Activity in Murine T Cells
Hathcock, K. S., Weng, N., Merica, R. R., Jenkins, M. K., & Hodes, R. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5702 · Cited by 69
Fetal Human Hematopoietic Stem Cells Can Differentiate Sequentially into Neural Stem Cells and Then Astrocytes In Vitro
Hao, H., Zhao, J. Y., Thomas, R., Parker, G. C., & Lyman, W. D. (2003) · Stem Cells and Development · doi:10.1089/152581603321210109 · Cited by 71
Stem Cells in Marine Organisms
Rinkevich, B., & Matranga, V. (2009) · Springer eBooks · doi:10.1007/978-90-481-2767-2 · Cited by 74
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 78
Hematopoietic Stem Cells: Transcriptional Regulation, Ex Vivo Expansion and Clinical Application
Aggarwal, R., Lu, J., Pompili, V. J., & Das, H. (2011) · Current Molecular Medicine · doi:10.2174/156652412798376125 · Cited by 72
Altered Telomere Nuclear Matrix Interactions and Nucleosomal Periodicity in Ataxia Telangiectasia Cells before and after Ionizing Radiation Treatment
Smilenov, L. B., Dhar, S., & Pandita, T. K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6963 · Cited by 69
Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?
Allsopp, R., & Weissman, I. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205314 · Cited by 71
Self-citation
Similar repopulating capacity of mitotically active and resting umbilical cord blood CD34+ cells in NOD/SCID mice
Wilpshaar, J., Falkenburg, J. H. F., Tong, X., Noort, W. A., Breese, R., Heilman, D., Kanhai, H. H. H., Orschell, C. M., & Srour, E. F. (2000) · Blood · doi:10.1182/blood.v96.6.2100.h8002100_2100_2107 · Cited by 70
Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass
Vasan, R. S., Demissie, S., Kimura, M., Cupples, L. A., White, C. C., Gardner, J. P., Cao, X., Levy, D. A., Benjamin, E. J., & Aviv, A. (2009) · Circulation · doi:10.1161/circulationaha.109.853895 · Cited by 69
Telomere length shortening in non-Hodgkin's lymphoma patients undergoing chemotherapy
Lee, J.-J., Nam, C.-E., Cho, S.-H., Park, K.-S., Chung, I.-J., & Kim, H.-J. (2003) · Annals of Hematology · doi:10.1007/s00277-003-0691-4 · Cited by 68
Red Blood Cell Size Is Inversely Associated with Leukocyte Telomere Length in a Large Multi-Ethnic Population
Kozlitina, J., & Garcia, C. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051046 · Cited by 69
Dynamics of Mutant Cells in Hierarchical Organized Tissues
Werner, B., Dingli, D., Lenaerts, T., Pacheco, J. M., & Traulsen, A. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002290 · Cited by 69
Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts
Westin, E. R., Chavez, E. A., Lee, K. M., Gourronc, F. A., Riley, S., Lansdorp, P. M., Goldman, F. D., & Klingelhutz, A. J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00288.x · Cited by 68
Self-citation
Role of telomere dysfunction in aging and its detection by biomarkers
von Figura, G., Hartmann, D., Song, Z., & Rudolph, K. L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0509-5 · Cited by 70
Werner Syndrome as an Example of Inflamm-aging: Possible Therapeutic Opportunities for a Progeroid Syndrome?
Davis, T., & Kipling, D. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.402 · Cited by 69
Does the reservoir for self-renewal stem from the ends?
Harrington, L. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207948 · Cited by 70
Hematopoietic stem cells and aging
Globerson, A. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00069-2 · Cited by 66
Maintenance of genomic integrity in hematopoietic stem cells
Naka, K., & Hirao, A. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0793-z · Cited by 68
Telomerase: A Potential Diagnostic and Therapeutic Tool in Canine Oncology
Argyle, D. J., & Nasir, L. (2003) · Veterinary Pathology · doi:10.1354/vp.40-1-1 · Cited by 66
Challenges in Umbilical Cord Blood Stem Cell Banking for Stem Cell Reviews and Reports
Ballen, K. K. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9105-x · Cited by 64
Telomere Biology and Telomere Diseases: Implications for Practice and Research
Young, N. S. (2010) · Hematology · doi:10.1182/asheducation-2010.1.30 · Cited by 66
Telomere Lengths in Cloned Transgenic Pigs1
Jiang, L., Carter, D. B., Xu, J., Yang, X., Prather, R. S., & Tian, X. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.022616 · Cited by 64
Modeling of replicative senescence in hematopoietic development
Marciniak-Czochra, A. K., Stiehl, T., & Wagner, W. (2009) · Aging · doi:10.18632/aging.100072 · Cited by 62
Stem cell‐derived angiogenic/vasculogenic cells: Possible therapies for tissue repair and tissue engineering
Zwaginga, J. J., & Doevendans, P. A. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03931.x · Cited by 64
Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
Nakamura, K., Takubo, K., Izumiyama‐Shimomura, N., Sawabe, M., Arai, T., Kishimoto, H., Fujiwara, M., Kato, M., Oshimura, M., Ishii, A., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.003 · Cited by 66
Cellular Memory and Hematopoietic Stem Cell Aging
Kamminga, L. M., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0345 · Cited by 63
Telomeres, senescence, and hematopoietic stem cells
Zimmermann, S., & Martens, U. M. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0469-4 · Cited by 66
Differentiation-Related Mechanisms Which Suppress DNA Replication
Coffman, F. D., & Studzinski, G. P. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4457 · Cited by 62
Different Kinetics of Senescence in Human Fibroblasts and Peritoneal Mesothelial Cells
Thomas, E., Al-Baker, E., Dropcova, S., Denyer, S. P., Ostad, S. N., Lloyd, A. W., Kill, I. R., & Faragher, R. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3760 · Cited by 62
Do telomerase antagonists represent a novel anti-cancer strategy?
Parkinson, E. K. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.1 · Cited by 62
Characterization of Serum-Free Ex Vivo–Expanded Hematopoietic Stem Cells Derived from Human Umbilical Cord Blood CD133 + Cells
Yao, C., Feng, Y., Lin, X., Chu, I., Hsieh, T., & Hwang, S. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.70 · Cited by 61
Catalytic Subunit of Human Telomerase Reverse Transcriptase Is an Independent Predictor of Survival in Patients Undergoing Curative Resection of Hepatic Colorectal Metastases: A Multicenter Analysis
Dômont, J., Pawlik, T. M., Boige, V., Rosé, M., Weber, J. C., Hoff, P. M., Brown, T. D., Zorzi, D., Morat, L., Pignon, J., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.944 · Cited by 61
Concise Review: Hematopoietic Stem Cell Aging, Life Span, and Transplantation
Zant, G. E. V., & Liang, Y. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0033 · Cited by 62
Cerebellar telomere length and psychiatric disorders
Zhang, D., Cheng, L., Craig, D. W., Redman, M., & Liu, C. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9338-0 · Cited by 60
“The mTL of most somatic cells is negatively correlated with age, although it varies greatly among individuals, even those in the same age group (Andrew et al. 2006; Okuda et al. 2000; Vasa-Nicotera et al. 2005; Vaziri et al. 1994; Vaziri et al. 1993).”
Background
Telomeres and Telomerase in the Control of Stem Cells
Lupatov, A. Y., & Yarygin, K. N. (2022) · Biomedicines · doi:10.3390/biomedicines10102335 · Cited by 64
Telomere dysfunction and its role in haematological cancer
Jones, C. H., Pepper, C. J., & Baird, D. M. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.09022.x · Cited by 60
Diagonal Earlobe Crease are Associated With Shorter Telomere in Male Japanese Patients With Metabolic Syndrome A Pilot Study
Higuchi, Y., Maeda, T., Guan, J.-Z., Oyama, J., Sugano, M., & Makino, N. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-0267 · Cited by 61
Human Umbilical Cord Blood Progenitor Cells are Attracted to Infarcted Myocardium and Significantly Reduce Myocardial Infarction Size
Henning, R. J., Burgos, J. D., Ondrovic, L. E., Sanberg, P. R., Balis, J. U., & Morgan, M. B. (2006) · Cell Transplantation · doi:10.3727/000000006783981611 · Cited by 60
Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy
Leach, N. T., Rehder, C. W., Jensen, K. O., Holt, S. E., & Jackson‐Cook, C. K. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.006 · Cited by 59
Human adipose-derived stem cells cultured in keratinocyte serum free medium: Donor’s age does not affect the proliferation and differentiation capacities
Ding, D., Chou, H.-L., Hung, W.-T., Liu, H.-W., & Chu, T. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-59 · Cited by 62
Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing
Wang, J., Morita, Y., Han, B., Niemann, S., Löffler, B., & Rudolph, K. L. (2016) · Nature Cell Biology · doi:10.1038/ncb3342 · Cited by 64
Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones
Schaniel, C., Gottar, M., Roosnek, E. E., Melchers, F., & Rolink, A. G. (2002) · Blood · doi:10.1182/blood.v99.8.2760 · Cited by 60
Chronic myeloid leukemia from basics to bedside
Thijsen, S. F. T., Schuurhuis, G. J., Oostveen, J. W. V., & Ossenkoppele, G. J. (1999) · Leukemia · doi:10.1038/sj.leu.2401565 · Cited by 60
Establishment of an Immortalized Human Hepatic Stellate Cell Line to Develop Antifibrotic Therapies
Shibata, N., Watanabe, T., Okitsu, T., Sakaguchi, M., Takesue, M., Kunieda, T., Omoto, K., Yamamoto, S., Tanaka, N., & Kobayashi, N. (2003) · Cell Transplantation · doi:10.3727/000000003108747064 · Cited by 59
Hematopoietic stem cells: challenges to expectations
Morrison, S. J., Wright, D. E., Cheshier, S. H., & Weissman, I. L. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80138-0 · Cited by 58
Development of Angiogenic Cell and Gene Therapy by Transplantation of Umbilical Cord Blood with Vascular Endothelial Growth Factor Gene
Ikeda, Y., Fukuda, N., Wada, M., Matsumoto, T., Satomi, A., Yokoyama, S.-I., Saito, S., Matsumoto, K., Kanmatsuse, K., & Mugishima, H. (2004) · Hypertension Research · doi:10.1291/hypres.27.119 · Cited by 59
ASSOCIATION BETWEEN OUTCOME AND TELOMERE DNA CONTENT IN PROSTATE CANCER
DONALDSON, L., Fordyce, C., Gilliland, F. D., Smith, A. Y., Feddersen, R. M., Joste, N. E., Moyzis, R. K., & Griffith, J. K. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)68239-0 · Cited by 60
Stem cells, telomerase and dyskeratosis congenita
Mason, P. J. (2003) · BioEssays · doi:10.1002/bies.10229 · Cited by 58
Leukocyte Telomere Length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's Disease: A pilot study
Movérare‐Skrtic, S., Johansson, P., Mattsson, N., Hansson, O., Wallin, A., Johansson, J.-O., Zetterberg, H., Blennow, K., & Svensson, J. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.005 · Cited by 58
Placental telomere length decreases with gestational age and is influenced by parity: A study of third trimester live-born twins
Gielen, M., Hageman, G. J., Pachen, D. M. F. A., Derom, C. A., VLIETINCK, R. F., & Zeegers, M. P. (2014) · Placenta · doi:10.1016/j.placenta.2014.05.010 · Cited by 57
Expansion of dendritic cell precursors from human CD34+ progenitor cells isolated from healthy donor blood; growth factor combination determines proliferation rate and functional outcome
Bontkes, H. J., de Gruijl, T. D., Schuurhuis, G. J., Scheper, R. J., Meijer, C. J. L. M., & Hooijberg, E. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.2.321 · Cited by 58
Neutral evolution in paroxysmal nocturnal hemoglobinuria
Dingli, D., Luzzatto, L., & Pacheco, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802749105 · Cited by 58
p53 and MDM2 alterations in osteosarcomas
Lonardo, F., Ueda, T., Huvos, A. G., Healey, J. H., & Ladanyi, M. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970415)79:8 · Cited by 147
The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II
Salpea, K. D., Nicaud, V., Tiret, L., Talmud, P. J., Humphries, S. E., & on behalf of the EARS II group (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0347-x · Cited by 57
Accumulation of DNA damage in the aged hematopoietic stem cell compartment
Beerman, I. (2016) · Seminars in Hematology · doi:10.1053/j.seminhematol.2016.11.001 · Cited by 55
Concise Review: Telomere Biology in Normal and Leukemic Hematopoietic Stem Cells
Drummond, M. W., Balabanov, S., Holyoake, T. L., & Brümmendorf, T. H. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0057 · Cited by 60
Umbilical cord blood cells for treatment of cerebral palsy; timing and treatment options
McDonald, C., Fahey, M. C., Jenkin, G., & Miller, S. (2017) · Pediatric Research · doi:10.1038/pr.2017.236 · Cited by 56
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells
Wang, J. C. Y., Warner, J. K., Erdmann, N., Lansdorp, P. M., Harrington, L. A., & Dick, J. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504161102 · Cited by 58
Self-citation
Telomere length inheritance and aging
Kappei, D., & Londoño‐Vallejo, A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.009 · Cited by 57
hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia
Campbell, L. J., Fidler, C., Eagleton, H., Peniket, A., Kušec, R., Gal, S., Littlewood, T. J., Wainscoat, J. S., & Boultwood, J. (2006) · Leukemia · doi:10.1038/sj.leu.2404141 · Cited by 58
Equine telomeres and telomerase in cellular immortalisation and ageing
Argyle, D. J., Ellsmore, V., Gault, E. A., Munro, A. F., & Nasir, L. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00104-0 · Cited by 56
Aging and Haemopoiesis
Chatta, G. S., & Dale, D. C. (1996) · Drugs & Aging · doi:10.2165/00002512-199609010-00004 · Cited by 56
Regulation of Senescence in Cancer and Aging
Kong, Y., Cui, H., Ramkumar, C., & Zhang, H. (2011) · Journal of Aging Research · doi:10.4061/2011/963172 · Cited by 61
The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters
Brouwers, B. A. H., Hatse, S., Lago, L. D., Neven, P., Vuylsteke, P., Dalmasso, B., Debrock, G., den Bulck, H. V., Smeets, A., Bechter, O. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8796 · Cited by 56
Questions to be answered regarding umbilical cord blood hematopoietic stem and progenitor cells and their use in‐transplantation
Broxmeyer, H. E. (1995) · Transfusion · doi:10.1046/j.1537-2995.1995.35895357903.x · Cited by 55
Biology of human hematopoietic stem and progenitor cells present in circulation
Mayani, H., Alvarado‐Moreno, J. A., & Flores-Guzmán, P. (2003) · Archives of Medical Research · doi:10.1016/j.arcmed.2003.08.004 · Cited by 55
Association between telomere length and VH gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications
Hultdin, M., Rosenquist, R., Thunberg, U., Tobin, G., Norrback, K.-F., Johnson, A., Sundström, C., & Roos, G. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600763 · Cited by 55
Human cord blood-derived primitive progenitors are enriched in CD34+c-kit− cells: correlation between long-term culture-initiating cells and telomerase expression
SAKABE, H., Yahata, N., Kimura, T., Zeng, Z., Minamiguchi, H., Kaneko, H., Mori, K., Ohyashiki, K., Ohyashiki, J. H., Toyama, K., et al. (1998) · Leukemia · doi:10.1038/sj.leu.2401001 · Cited by 55
Telomeres, hidden mosaicism, loss of heterozygosity, and complex genetic traits
Aviv, A., & Aviv, H. (1998) · Human Genetics · doi:10.1007/s004390050774 · Cited by 55
The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems
Tümpel, S., & Rudolph, K. L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06547.x · Cited by 59
Possibility of selection of chondrogenic progenitor cells by telomere length in FGF‐2‐expanded mesenchymal stromal cells
Yanada, S., Ochi, M., Kojima, K., Sharman, P., Yasunaga, Y., & Hiyama, E. (2006) · Cell Proliferation · doi:10.1111/j.1365-2184.2006.00397.x · Cited by 54
Mankind’s first natural stem cell transplant
Tolosa, J. N., Park, D., Eve, D. J., Klasko, S. K., Borlongan, C. V., & Sanberg, P. R. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01029.x · Cited by 54
Association Between Left Ventricular Mass and Telomere Length in a Population Study
Kuznetsova, T., Codd, V., Brouilette, S., Thijs, L., González, A., Jin, Y., Richart, T., van der Harst, P., Dı́ez, J., Staessen, J. A., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq142 · Cited by 54
Telomerase deficiency does not alter bleomycin-induced fibrosis in mice
Degryse, A. L., Xu, X. C., Newman, J., Mitchell, D. B., Tanjore, H., Polosukhin, V. V., Jones, B. R., McMahon, F. B., Gleaves, L. A., Phillips, J. A., et al. (2012) · Experimental Lung Research · doi:10.3109/01902148.2012.658148 · Cited by 57
Acceleration of Telomere Loss by Chemotherapy Is Greater in Older Patients with Locally Advanced Head and Neck Cancer
Unryn, B. M., Hao, D., Glück, S., & Riabowol, K. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0486 · Cited by 55
Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita
Goldman, F. D., Aubert, G., Klingelhutz, A. J., Hills, M., Cooper, S., Hamilton, W. S., Schlueter, A. J., Lambie, K., Eaves, C. J., & Lansdorp, P. M. (2008) · Blood · doi:10.1182/blood-2007-10-120204 · Cited by 54
Self-citation
Neural stem cells in aging and disease
Limke, T. L., & Rao, M. S. (2002) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2002.tb00451.x · Cited by 55
Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae
Austriaco, N. P. G., & Guarente, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9768 · Cited by 54
Impaired telomerase activity in uninfected haematopoietic progenitors in HIV-1-infected patients
Vignoli, M., Stecca, B. A., Furlini, G., Re, M. C., Mantovani, V., Zauli, G., Visani, G., Colangeli, V., & Plaça, M. L. (1998) · AIDS · doi:10.1097/00002030-199809000-00006 · Cited by 54
Models of initiation of replicative senescence by loss of telomeric DNA
Allsopp, R. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02008-x · Cited by 54
Self-citation
Genome instability of ageing stem cells—Induction and defence mechanisms
Burkhalter, M. D., Rudolph, K. L., & Sperka, T. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.004 · Cited by 54
Cord Blood Mesenchymal Stem Cells: Potential Use in Neurological Disorders
El‐Badri, N. S., Hakki, A., Saporta, S., Liang, X., Madhusodanan, S., Willing, A. E., Sanberg, C. D., & Sanberg, P. R. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.497 · Cited by 53
Telomere Dynamics and Aging
Aubert, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397898-1.00004-9 · Cited by 57
Stem and progenitor cells in human umbilical cord blood
Lee, M. W., Jang, I. K., Yoo, K. H., Sung, K. W., & Koo, H. H. (2010) · International Journal of Hematology · doi:10.1007/s12185-010-0619-4 · Cited by 52

Authors: Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M.
Affiliations: Geron (United States) (US)
ORCID: Allsopp, R C
Lansdorp, P M
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1994-10-11
Volume: 91
Issue: 21
Pages: 9857-9860
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.91.21.9857
PMC: PMC44916
OpenAlex: W2068409711
Cited by: 1,132
References: 41
Citations by year: 2026: 7 · 2025: 12 · 2024: 5 · 2023: 11 · 2022: 22 · 2021: 14 · 2020: 31 · 2019: 22 · 2018: 20 · 2017: 24 · 2016: 20 · 2015: 29 · 2014: 36 · 2013: 40 · 2012: 39
FWCI: 26.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG09383A)
National Institute of Allergy and Infectious Diseases (AI 29524)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: hematopoietic stem cells, telomere length, cellular senescence, stem cell aging, bone marrow, fetal liver, umbilical cord blood, hematopoiesis, gene therapy
MeSH terms: Adolescent, Adult, Aging, Bone Marrow, DNA, Fetal Blood, Fetus, Hematopoietic Stem Cells, Humans, Liver, Middle Aged, Mitosis, Antigens, CD, Telomere

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks