Cited by 1,132Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell TransplantationMesenchymal stem cell research

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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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Vaziri, H, Dragowska, W, Allsopp, R C, Thomas, T E, Harley, C B, Lansdorp, P M·1994·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.91.21.9857PMC PMC44916

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Abstract

The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of telomeric DNA from the ends of human chromosomes with each somatic cell division eventually reaches a critical point that triggers cellular senescence. We now show that candidate human stem cells with a CD34+CD38lo phenotype that were purified from adult bone marrow have shorter telomeres than cells from fetal liver or umbilical cord blood. We also found that cells produced in cytokine-supplemented cultures of purified precursor cells show a proliferation-associated loss of telomeric DNA. These findings strongly suggest that the proliferative potential of most, if not all, hematopoietic stem cells is limited and decreases with age, a concept that has widespread implications for models of normal and abnormal hematopoiesis as well as gene therapy.

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Self-citation
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Self-citation
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096
Self-citation
Untitled work
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
Morin, G. B. (1989) · Cell · doi:10.1016/0092-8674(89)90035-4 · Cited by 1,495
Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.
Civin, C., Strauss, L. C., Brovall, C., Fackler, M., Schwartz, J. F., & Shaper, J. H. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.1.157 · Cited by 1,200

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Rebel, V. I., Miller, C., Eaves, C. J., & Lansdorp, P. (1996) · Blood · doi:10.1182/blood.v87.8.3500.bloodjournal8783500 · Cited by 223
Self-citation
Telomere dynamics and telomerase activity in in vitro immortalised human cells
Bryan, T. M., & Reddel, R. R. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00065-8 · Cited by 227
Age‐related impairment of mesenchymal progenitor cell function
Stolzing, A., & Scutt, A. M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00213.x · Cited by 219
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00681-6 · Cited by 221
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Bhatia, R. (2013) · Seminars in Oncology · doi:10.1053/j.seminoncol.2013.09.013 · Cited by 220
Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence
Lord, R. V., Salonga, D. S., Danenberg, K. D., Peters, J. H., DeMeester, T. R., Park, J. M., Johansson, J., Skinner, K. A., Chandrasoma, P., DeMeester, S. R., et al. (2000) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(00)80049-9 · Cited by 220
Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow
Yui, J., Chiu, C.-P., & Lansdorp, P. M. (1998) · Blood · doi:10.1182/blood.v91.9.3255 · Cited by 216
Self-citation
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216
Life histories of myeloproliferative neoplasms inferred from phylogenies.
Williams, N., Lee, J., Mitchell, E., Moore, L., Baxter, E. J., Hewinson, J., Dawson, K. J., Menzies, A. H., Godfrey, A. L., Green, A. R., et al. (2022) · RePEc: Research Papers in Economics · doi:10.17863/cam.80309 · Cited by 216
IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire
Soares, M. V. D., Soares, D., Borthwick, N., Maini, M. K., Janossy, G., Salmon, M., & Akbar, A. N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.5909 · Cited by 216
Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents
Sloter, E. D., Nath, J., Eskenazi, B., & Wyrobek, A. J. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.07.043 · Cited by 212
Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging
de Haan, G., & Van Zant, G. (1999) · Blood · doi:10.1182/blood.v93.10.3294.410k07_3294_3301 · Cited by 208
Impact of genomic damage and ageing on stem cell function
Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology · doi:10.1038/ncb2928 · Cited by 207
Position Statement on Human Aging
Olshansky, S. J., Hayflick, L., & Carnes, B. A. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.8.b292 · Cited by 202
From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
Vaziri, H., & Benchimol, S. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02025-x · Cited by 209
Self-citation
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
Weng, N., Palmer, L. D., Levine, B. L., Lane, H. C., June, C. H., & Hodes, R. J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01026.x · Cited by 201
Telomere length and heredity: Indications of paternal inheritance
Nordfjäll, K., Larefalk, Å., Lindgren, P., Holmberg, D., & Roos, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501724102 · Cited by 205
Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.
Harada, H., Nakagawa, H., Oyama, K., Takaoka, M., Andl, C. D., Jacobmeier, B., von Werder, A., Enders, G. H., Opitz, O. G., & Rustgi, A. K. (2003) · PubMed · Cited by 197
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Sharma, A. K., Nelson, M. C., Brandt, J., Wessman, M., Mahmud, N., Weller, K. P., & Hoffman, R. (2001) · Blood · doi:10.1182/blood.v97.2.426 · Cited by 199
Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry
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Self-citation
Telomerase regulation during entry into the cell cycle in normal human T cells.
Buchkovich, K. J., & Greider, C. W. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.9.1443 · Cited by 198
High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage
Albanell, J., Engelhardt, M., Han, W., Moore, M. A. S., Lonardo, F., Rusch, V., Langenfeld, J., Klimstra, D., Venkatraman, E., & Dmitrovsky, E. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.21.1609 · Cited by 193
In vivo telomere dynamics of human hematopoietic stem cells
Notaro, R., Cimmino, A., Tabarini, D., Rotoli, B., & Luzzatto, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13782 · Cited by 195
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Harley, C. B., Liu, W., Blasco, M. A., Vera, E., Andrews, W. H., Briggs, L., & Raffaele, J. M. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1085 · Cited by 200
Self-citation
The role of stem cells in aging
Zant, G. E. V., & Liang, Y. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00088-2 · Cited by 197
Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells
Allsopp, R., Cheshier, S. H., & Weissman, I. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.917 · Cited by 195
Self-citation
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Soundararajan, M., & Kannan, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26860 · Cited by 198
Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer.
Engelhardt, M. M., Drullinsky, P. R., Guillem, J. G., & Moore, M. A. S. (1997) · PubMed · Cited by 189
The theory of bipolar disorder as an illness of accelerated aging: implications for clinical care and research
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183
Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
Adams, P. D., Jasper, H., & Rudolph, K. L. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.002 · Cited by 182
Dyskeratosis congenita, stem cells and telomeres
Kirwan, M., & Dokal, I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.010 · Cited by 180
Clinical implications of telomerase in cancer
Kim, N. W. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00057-9 · Cited by 179
Telomerase Activity Concentrates in the Mitotically Active Segments of Human Hair Follicles
Ramirez, R. D., Wright, W. E., Shay, J. W., & Taylor, R. S. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12285654 · Cited by 174
Telomere Length and Use of Immunosuppressive Medications in Idiopathic Pulmonary Fibrosis
Newton, C. A., Zhang, D., Oldham, J. M., Kozlitina, J., Ma, S., Martínez, F. J., Raghu, G., Noth, I., & Garcia, C. K. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201809-1646oc · Cited by 181
Human adult stem cells from diverse origins: An overview from multiparametric immunophenotyping to clinical applications
de Sousa, B. R., Parreira, R. C., Fonseca, E. A., Amaya, M. J., Tonelli, F. M. P., Lacerda, S. M. D. S. N., Lalwani, P. J., Santos, A. K., Gomes, K. N., Ulrich, H., et al. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22402 · Cited by 175
Identification of self-renewing myoblasts in the progeny of single human muscle satellite cells
Baroffio, A., Hamann, M., Bernheim, L., Bochaton‐Piallat, M., Gabbiani, G., & Bader, C. R. (1996) · Differentiation · doi:10.1046/j.1432-0436.1996.6010047.x · Cited by 170
The molecular genetics of the telomere biology disorders
Bertuch, A. A. (2015) · RNA Biology · doi:10.1080/15476286.2015.1094596 · Cited by 173
Stem cells and cellular pedigrees – a conceptual introduction
Loeffler, M., & Potten, C. S. (1997) · Elsevier eBooks · doi:10.1016/b978-012563455-7/50002-7 · Cited by 169
Refining the telomere-telomerase hypothesis of aging and cancer
Holt, S. E., Shay, J. W., & Wright, W. E. (1996) · Nature Biotechnology · doi:10.1038/nbt0796-836 · Cited by 168
Rationale, design, methods and baseline characteristics of the Asklepios Study
Rietzschel, E., Buyzere, M. D., Bekaert, S., Segers, P., Bacquer, D. D., Cooman, L., Damme, P. V., Cassiman, P., Langlois, M. R., Oostveldt, P. V., et al. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328012c380 · Cited by 167
Telomere shortening and ageing
Jiang, H., Ju, Z., & Rudolph, K. L. (2007) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-007-0480-0 · Cited by 165
New trends in umbilical cord blood transplantation
Ballen, K. K. (2005) · Blood · doi:10.1182/blood-2004-10-4125 · Cited by 165
Age‐independent telomere length predicts fitness in two bird Species
Pauliny, A., WAGNER, R. H., Augustin, J., Szép, T., & Blomqvist, D. (2006) · Molecular Ecology · doi:10.1111/j.1365-294x.2006.02862.x · Cited by 176
Telomere attrition as ageing biomarker.
Bekaert, S., Meyer, T. D., & Oostveldt, P. V. (2005) · PubMed · Cited by 158
Telomere shortening impairs organ regeneration by inhibiting cell cycle re‐entry of a subpopulation of cells
Satyanarayana, A., Wiemann, S. U., Buer, J., Lauber, J., Dittmar, K. E. J., Wüstefeld, T., Blasco, M. A., Manns, M. P., & Rudolph, K. L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg367 · Cited by 158
The role of insulin and IGF-1 signaling in longevity
Katić, M., & Kahn, C. R. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4297-y · Cited by 163
Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids.
Wright, W. E., Brasiskyte, D., Piatyszek, M. A., & Shay, J. W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00519.x · Cited by 158
Human diseases of telomerase dysfunction: insights into tissue aging
Garcia, C. K., Wright, W. E., & Shay, J. W. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm644 · Cited by 161
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Nature Medicine · doi:10.1038/nm0403-369 · Cited by 155
Self-citation
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Weng, N., Hathcock, K. S., & Hodes, R. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80597-x · Cited by 157
In situ analysis of changes in telomere size during replicative aging and cell transformation.
Henderson, S. C., Allsopp, R., Spector, D. L., Wang, S. S., & Harley, C. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.1.1 · Cited by 154
Self-citation
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Khatib, A., Nip, J., Fallavollita, L., Lehmann, M., Jensen, G. S., & Brodt, P. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(200002)9999:9999 · Cited by 15
Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
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Mankouri, H. W., Huttner, D., & Hickson, I. D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.211 · Cited by 149
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Stewart, S. A., & Weinberg, R. A. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0339 · Cited by 152
Telomerase activity is maintained throughout the lifespan of long-lived birds
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Spyridopoulos, I., Hoffmann, J., Aicher, A., Brümmendorf, T. H., Doerr, H. W., Zeiher, A. M., & Dimmeler, S. (2009) · Circulation · doi:10.1161/circulationaha.109.854299 · Cited by 147
Telomeres, sex, reactive oxygen species, and human cardiovascular aging
Aviv, A. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0377-8 · Cited by 138
Telomeres and telomerase in hematologic neoplasia
Ohyashiki, J. H., Sashida, G., Tauchi, T., & Ohyashiki, K. (2002) · Oncogene · doi:10.1038/sj.onc.1205075 · Cited by 142
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Ness, K. K., Kirkland, J. L., Gramatges, M. M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Pluijm, S. M. F., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.7467 · Cited by 143
Telomere length regulation during postnatal development and ageing in Mus spretus
Coviello-McLaughlin, G. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.3051 · Cited by 144
Age dependent aneuploidy and telomere length of the human vascular endothelium
Aviv, H., Khan, M. Y., Skurnick, J., Okuda, K., Kimura, M., Gardner, J., Priolo, L., & Aviv, A. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00506-8 · Cited by 141
Intercellular adhesions as determinants of tissue assembly and malignant invasion
Steinberg, M. S., & Foty, R. A. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199711)173:2 · Cited by 43
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Counter, C. M. (1996) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/s0165-1110(96)90006-8 · Cited by 139
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Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 140
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Nelson, N. D., & Bertuch, A. A. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.06.008 · Cited by 140
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Telomere length regulation in mice is linked to a novel chromosome locus
Zhu, L., Hathcock, K. S., Hande, M. P., Lansdorp, P. M., Seldin, M. F., & Hodes, R. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8648 · Cited by 138
Self-citation
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Brümmendorf, T. H., Dragowska, W. H., Zijlmans, J. M. J. M., Thornbury, G., & Lansdorp, P. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.6.1117 · Cited by 134
Self-citation
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Sunderkötter, C. H. (1997) · Archives of Dermatology · doi:10.1001/archderm.1997.03890460078009 · Cited by 133
Synchrony in telomere length of the human fetus
Youngren, K., Jeanclos, E., Aviv, H., Kimura, M., Stock, J., Hanna, M., Skurnick, J., Bardeguez, A., & Aviv, A. (1998) · Human Genetics · doi:10.1007/s004390050755 · Cited by 130
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Palmer, L. D., Weng, N.-P., Levine, B. L., June, C. H., Lane, H. C., & Hodes, R. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1381 · Cited by 129
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Kamminga, L. M., van Os, R., Ausema, A., Noach, E. J. K., Weersing, E., Dontje, B., Vellenga, E., & de Haan, G. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0066 · Cited by 128
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Warren, L. A., & Rossi, D. J. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.010 · Cited by 128
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Falandry, C., Bonnefoy, M., Freyer, G., & Gilson, É. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.1432 · Cited by 133
Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging
Zhang, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20919 · Cited by 136
Sex chromosome aneuploidy and aging
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Authors: Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M.
Affiliations: Geron (United States) (US)
ORCID: Allsopp, R C
Lansdorp, P M
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1994-10-11
Volume: 91
Issue: 21
Pages: 9857-9860
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.91.21.9857
PMC: PMC44916
OpenAlex: W2068409711
Cited by: 1,132
References: 41
Citations by year: 2026: 7 · 2025: 12 · 2024: 5 · 2023: 11 · 2022: 22 · 2021: 14 · 2020: 31 · 2019: 22 · 2018: 20 · 2017: 24 · 2016: 20 · 2015: 29 · 2014: 36 · 2013: 40 · 2012: 39
FWCI: 26.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG09383A)
National Institute of Allergy and Infectious Diseases (AI 29524)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: hematopoietic stem cells, telomere length, cellular senescence, stem cell aging, bone marrow, fetal liver, umbilical cord blood, hematopoiesis, gene therapy
MeSH terms: Adolescent, Adult, Aging, Bone Marrow, DNA, Fetal Blood, Fetus, Hematopoietic Stem Cells, Humans, Liver, Middle Aged, Mitosis, Antigens, CD, Telomere

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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

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