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A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
Open accessAbstract
Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta (TGF-beta) superfamily, have been implicated in bone formation and the regulation of early development. To better understand the roles of BMPs in Xenopus laevis embryogenesis, we have cloned a cDNA coding for a serine/threonine kinase receptor that binds BMP-2 and BMP-4. To analyze its function, we attempted to block the BMP signaling pathway in Xenopus embryos by using a dominant-negative mutant of the BMP receptor. When the mutant receptor lacking the putative serine/threonine kinase domain was expressed in ventral blastomeres of Xenopus embryos, these blastomeres were respecified to dorsal mesoderm, eventually resulting in the formation of a secondary body axis. These findings suggest that endogenous BMP-2 and BMP-4 are involved in the dorsal-ventral specification in the embryo and that ventral fate requires induction rather than resulting from an absence of dorsal specification.
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Cited by
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Metadata
- Authors
- Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K., & Ueno, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-10-25
- Volume
- 91
- Issue
- 22
- Pages
- 10255-10259
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074597244
- Cited by
- 447
- References
- 0
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. https://app.cochat.ai/papers/10.1073/pnas.91.22.10255
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- Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K., & Ueno, N. (1994). A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.22.10255
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
