Cited by 1,608Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationRenal and related cancers

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, Andrei, Wu, Wei, Delius, Hajo, Monaghan, A. Paula, Blumenstock, Claudia, Niehrs, Christof·1998·Nature

Abstract

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.

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Crossref · 10.1038/34848

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  • A number of secreted proteins that bind to Wnts and prevent their interaction with either Fz or LRP5/6 to antagonize Wnt signaling have been identified, including Dickkopf (Dkk) proteins, Wnt-inhibitor protein (WIF), soluble Frizzled-related proteins (SFRP), Cerebrus, Frzb and Wise.

    “In the extra-cellular matrix, a number of secreted proteins that bind to Wnts and prevent their interaction with either Fz or LRP5/6 to antagonize Wnt signaling have been identified. These include Dickkopf (Dkk) proteins,16 Wnt-inhibitor protein (WIF),17 soluble Frizzled-related proteins (SFRP),18 Cerebrus,19 Frzb20 and the context dependent Wnt inhibitor Wise.21”

    From Wnt signal transduction pathways (2008) · cites this paper as [16]

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Authors
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C.
Affiliations
German Cancer Research Center (DE)
Venue
Nature
Published
1998-01
Volume
391
Issue
6665
Pages
357-362
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1564357553
Cited by
1,608
References
47
Citations by year
2026: 7 · 2025: 31 · 2024: 28 · 2023: 47 · 2022: 44 · 2021: 65 · 2020: 50 · 2019: 41 · 2018: 57 · 2017: 71 · 2016: 54 · 2015: 65 · 2014: 69 · 2013: 63 · 2012: 75
FWCI
18.37
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
Keywords
DKK1, Spemann organizer, head induction, Wnt signaling, Wnt inhibitors, secreted proteins, Xenopus embryo, amphibian embryonic development, gene family
MeSH terms
Animals, Cloning, Molecular, Embryonic Induction, Multigene Family, Head, Molecular Sequence Data, Proteins, Proto-Oncogene Proteins, Xenopus, Signal Transduction, Xenopus Proteins, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Embryonic Development, Wnt Proteins

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