The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.
Open accessAbstract
High levels of tissue advanced glycation end products (AGEs) that result from the spontaneous modification of proteins by glucose occur in diabetes and aging. To address the potential pathogenic role of AGEs in the glomerulosclerosis of diabetes or nephrosclerosis of aging, doses of AGE-modified rat albumin (25 mg per kg per day, i.v.) sufficient to elevate circulating AGE levels to the range of diabetic serum were administered daily to healthy rats alone or in combination with the AGE inhibitor aminoguanidine. After 5 months, the AGE content of renal tissues in AGE-treated rats rose to 50% above controls (P < 0.025), whereas serum contained 2.8-fold greater AGE levels (P < 0.025). Light and electron microscopy of kidneys from AGE-treated rats revealed a more than 50% increase in glomerular volume compared to controls (P < 0.001), significant periodic acid/Schiff reagent-positive deposits, basement membrane widening, and mesangial extracellular matrix increase and indicated significant glomerulosclerosis compared to untreated (P < 0.002) or albumin-treated controls (P < 0.002). These changes were associated with significant loss of protein (P < 0.005) and albumin (P < 0.002) in the urine of AGE-treated rats compared to controls. Cotreatment with aminoguanidine markedly limited both the structural and functional defects. These in vivo data demonstrate that AGEs influence glomerular structure and function in a manner leading to glomerulosclerosis. The effects are AGE-specific, as they are ameliorated by a pharmacological AGE inhibitor, aminoguanidine.
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Cites
Advanced Glycosylation End Products in Patients with Diabetic Nephropathy
Makita, Z., Radoff, S., Rayfield, E. J., Yang, Z., Skolnik, E., Delaney, V., Friedman, E. A., Cerami, A., & Vlassara, H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109193251202 · Cited by 918
Self-citationVlassara, H., Bucala, R., & Striker, L. J. (1994) · PubMed · Cited by 848
Self-citationAminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction
Corbett, J. A., Tilton, R. G., Chang, K., Hasan, K. S., Ido, Y., Wang, J. L., Sweetland, M. A., Lancaster, J. R., Williamson, J. R., & McDaniel, M. L. (1992) · Diabetes · doi:10.2337/diab.41.4.552 · Cited by 628
Immunochemical detection of advanced glycosylation end products in vivo.
Makita, Z., Vlassara, H., Cerami, A., & Bucala, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42741-x · Cited by 491
Self-citationModified assay for determination of hydroxyproline in a tissue hydrolyzate
Edwards, C. A., & O'Brien, W. D. (1980) · Clinica Chimica Acta · doi:10.1016/0009-8981(80)90192-8 · Cited by 476
Bucala, R., Makita, Z., Vega, G., Grundy, S., Koschinsky, T., Cerami, A., & Vlassara, H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9441 · Cited by 474
Self-citationVlassara, H., Fuh, H., Makita, Z., Krungkrai, S., Cerami, A., & Bucala, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12043 · Cited by 377
Self-citationReactive glycosylation endproducts in diabetic uraemia and treatment of renal failure
Makita, Z., Bucala, R., Rayfield, E. J., Fuh, H., Manogue, K. R., Cerami, A., Viassara, H., Friedman, E. A., Kaufman, A. M., Korbet, S. M., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92935-1 · Cited by 373
Self-citationEffects of aging on the renal glomerulus
Anderson, S., & Brenner, B. M. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90718-7 · Cited by 346
Hayase, F., Nagaraj, R. H., Miyata, S., Njoroge, F. G., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84914-1 · Cited by 306
Cited by
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,455
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
Goh, S.-Y., & Cooper, M. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1817 · Cited by 987
Koschinsky, T., He, C.-J., Mitsuhashi, T., Bucala, R., Liu, C., Buenting, C., Heitmann, K., & Vlassara, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6474 · Cited by 792
Self-citationDiabetes and advanced glycation endproducts
Vlassara, H., & Palace, M. R. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00932.x · Cited by 697
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Metadata
- Authors
- Vlassara, H., Striker, L. J., Teichberg, S., Fuh, H., Li, Y. M., & Steffes, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-11-22
- Volume
- 91
- Issue
- 24
- Pages
- 11704-11708
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068793587
- Cited by
- 462
- References
- 16
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Vlassara, H., Striker, L. J., Teichberg, S., Fuh, H., Li, Y. M., & Steffes, M. (1994). Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.24.11704
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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