The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction
Abstract
Increased blood flow and vascular leakage of proteins preferentially affect tissues that are sites of diabetic complications in humans and animals. These vascular changes in diabetic rats are largely prevented by aminoguanidine. Glucose-induced vascular changes in nondiabetic rats are also prevented by aminoguanidine and by NG-monomethyl-L-arginine (NMMA), an established inhibitor of nitric oxide (NO·) formation from L-arginine. Aminoguanidine and NMMA are equipotent inhibitors of interleukin-1 β-induced 1) nitrite formation (an oxidation product of NO·) and cGMP accumulation by the rat β-cell insulinoma cell line RINm5F, and 2) inhibition of glucose-stimulated insulin secretion and formation of iron-nitrosyl complexes by islets of Langerhans. In contrast, NMMA is ∼ 40 times more potent than aminoquanidine in elevating blood pressure in nondiabetic rats. These results demonstrate that aminoguanidine inhibits NO. production and suggest a role for NO· in the pathogenesis of diabetic vascular complications.
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Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Cited by
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312
Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
Misko, T. P., Moore, W. M., Kasten, T. P., Nickols, G. A., Corbett, J. A., Tilton, R. G., McDaniel, M. L., Williamson, J. R., & Currie, M. G. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90357-n · Cited by 721
Self-citationSzabó, C., Southan, G. J., & Thiemermann, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12472 · Cited by 406
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Novel inhibitors of advanced glycation endproducts
Rahbar, S., & Figarola, J. L. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.009 · Cited by 329
Metadata
- Authors
- Corbett, J. A., Tilton, R. G., Chang, K., Hasan, K. S., Ido, Y., Wang, J. L., Sweetland, M. A., Lancaster, J. R., Williamson, J. R., & McDaniel, M. L.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1992-04-01
- Volume
- 41
- Issue
- 4
- Pages
- 552-556
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2077824574
- Cited by
- 628
- References
- 1
- FWCI
- 27.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction. https://app.cochat.ai/papers/10.2337/diab.41.4.552
- The paper
- Corbett, J. A., Tilton, R. G., Chang, K., Hasan, K. S., Ido, Y., Wang, J. L., Sweetland, M. A., Lancaster, J. R., Williamson, J. R., & McDaniel, M. L. (1992). Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction. Diabetes. https://doi.org/10.2337/diab.41.4.552
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