The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin.
Open accessAbstract
Caveolae are small invaginations of the plasma membrane 50-100 nm in diameter. Since calcium channels, inositol 1,4,5-trisphosphate receptors, and heterotrimeric GTP-binding proteins (G proteins) are localized in caveolae, they may participate in signal transduction by G protein-coupled receptors. Here we show that the G protein-coupled endothelin receptor subtype A (ETA) and its bound endothelin ligand are found in plasma membrane caveolae. ETA and its bound ligand coimmunoprecipitate with caveolin, a structural component of caveolae, in extracts of cells expressing transfected ETA receptors. Confocal fluorescence microscopy shows colocalization of ETA receptors and caveolin in micropatches at or near the plasma membrane, in the absence of endothelin ligands. These observations demonstrate a functional role for plasma membrane caveolae in signal transduction by this G protein-coupled receptor.
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells
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Self-citationTHE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE
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Cited by
Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin
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Self-citationIdentification, sequence, and expression of caveolin-2 defines a caveolin gene family.
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CO AS A CELLULAR SIGNALING MOLECULE
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Metadata
- Authors
- Chun, M., Liyanage, U. K., Lisanti, M. P., & Lodish, H. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-11-22
- Volume
- 91
- Issue
- 24
- Pages
- 11728-11732
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073250749
- Cited by
- 334
- References
- 25
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Chun, M., Liyanage, U. K., Lisanti, M. P., & Lodish, H. F. (1994). Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.24.11728
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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