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Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking
Abstract
Glycosyl-phosphatidylinositol (GPI)-anchored proteins have been reported to reside in clusters collected over small membrane invaginations called caveolae. The detection of different GPI-anchored proteins with fluorescently labeled monoclonal antibodies showed that these proteins are not constitutively concentrated in caveolae; they enter these structures independently after cross-linking with polyclonal secondary antibodies. Analysis of the cell surface distribution of the GPI-anchored folate receptor by electron microscopy confirms these observations. Thus, multimerization of GPI-anchored proteins regulates their sequestration in caveolae, but in the absence of agents that promote clustering they are diffusely distributed over the plasma membrane.
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Citations
Cited by
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
Pathways of clathrin-independent endocytosis
Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556
Self-citationGPI-anchored proteins are organized in submicron domains at the cell surface
Varma, R., & Mayor, S. (1998) · Nature · doi:10.1038/29563 · Cited by 1,209
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Metadata
- Authors
- Mayor, S., Rothberg, K. G., & Maxfield, F. R.
- Venue
- Science
- Published
- 1994-06-24
- Volume
- 264
- Issue
- 5167
- Pages
- 1948-1951
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092164532
- Cited by
- 510
- References
- 0
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking. https://app.cochat.ai/papers/10.1126/science.7516582
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- Mayor, S., Rothberg, K. G., & Maxfield, F. R. (1994). Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking. Science. https://doi.org/10.1126/science.7516582
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