The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Retroviral integrase domains: DNA binding and the recognition of LTR sequences
Open accessAbstract
Integration of retroviral DNA into the host chromosome requires a virus-encoded integrase (IN). IN recognizes, cuts and then joins specific viral DNA sequences (LTR ends) to essentially random sites in host DNA. We have used computer-assisted protein alignments and mutagenesis in an attempt to localize these functions within the avian retroviral IN protein. A comparison of the deduced amino acid sequences for 80 retroviral/retrotransposon IN proteins reveals strong conservation of an HHCC N-terminal 'Zn finger'-like domain, and a central D(35)E region which exhibits striking similarities with sequences deduced for bacterial IS elements. We demonstrate that the HHCC region is not required for DNA binding, but contributes to specific recognition of viral LTRs in the cutting and joining reactions. Deletions which extend into the D(35)E region destroy the ability of IN to bind DNA. Thus, we propose that the D(35)E region may specify a DNA-binding/cutting domain that is conserved throughout evolution in enzymes with similar functions.
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Cites
Origins and evolutionary relationships of retroviruses
Doolittle, R. F., Johnson, M. S., & McClure, M. A. (1989) · The Quarterly Review of Biology · doi:10.1086/416128 · Cited by 577
Johnson, M. S., McClure, M. A., Feng, D. F., Gray, J., & Doolittle, R. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7648 · Cited by 480
Retroviral DNA integration: structure of an integration intermediate
Fujiwara, T., & Mizuuchi, K. (1988) · Cell · doi:10.1016/0092-8674(88)90071-2 · Cited by 385
Katzman, M., Katz, R. A., Skalka, A. M., & Leis, J. (1989) · Journal of Virology · doi:10.1128/jvi.63.12.5319-5327.1989 · Cited by 311
Self-citationRoth, M. J., Schwartzberg, P. L., & Goff, S. P. (1989) · Cell · doi:10.1016/0092-8674(89)90401-7 · Cited by 263
Schwartzberg, P., Colicelli, J., & Goff, S. P. (1984) · Cell · doi:10.1016/0092-8674(84)90439-2 · Cited by 242
Sequence and spacing requirements of a retrovirus integration site
Colicelli, J., & Goff, S. P. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90378-6 · Cited by 198
Cited by
Engelman, A., & Craigie, R. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6361-6369.1992 · Cited by 519
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
Engelman, A., Englund, G., Orenstein, J. M., Martin, M. A., & Craigie, R. (1995) · Journal of Virology · doi:10.1128/jvi.69.5.2729-2736.1995 · Cited by 445
Chen, J. C.-H., Krucinski, J., Miercke, L. J. W., Finer-Moore, J. S., Tang, A. H., Leavitt, A. D., & Stroud, R. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150220297 · Cited by 404
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
Cai, M., Zheng, R., Caffrey, M., Craigie, R., Clore, G. M., & Gronenborn, A. M. (1997) · Nature Structural Biology · doi:10.1038/nsb0797-567 · Cited by 342
Doak, T. G., Doerder, F. P., Jahn, C. L., & Herrick, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.942 · Cited by 323
Metadata
- Authors
- Khan, E., Mack, J. P. G., Katz, R. A., Kulkosky, J., & Skalka, A. M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1991
- Volume
- 19
- Issue
- 4
- Pages
- 851-860
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1995455922
- Cited by
- 290
- References
- 7
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Khan, E., Mack, J. P. G., Katz, R. A., Kulkosky, J., & Skalka, A. M. (1991). Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Research. https://doi.org/10.1093/nar/19.4.851
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
