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Cited by 273

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.

Open access
Pothoulakis, C, Castagliuolo, I, LaMont, J T, Jaffer, A, O'Keane, J C, Snider, R M, Leeman, S E·1994·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.91.3.947
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Abstract

Toxin A from Clostridium difficile mediates acute inflammatory enterocolitis in experimental animals, while cholera toxin causes noninflammatory secretory diarrhea. The purpose of this study was to investigate whether an antagonist to the peptide substance P, a constituent of primary sensory neurons known to participate in inflammatory responses, would inhibit toxin A-mediated enteritis in the rat ileum. Pretreatment of rats with CP-96,345 (2.5 mg per kg of body weight), a substance P antagonist, dramatically inhibited fluid secretion (P < 0.01) and mannitol permeability (P < 0.01) in ileal loops exposed to toxin A. The protective effects, which were dose dependent, caused a significant reduction of inflammation in the lamina propria, reduction of the necrosis of intestinal epithelial cells, and complete inhibition of toxin A-mediated release of rat mast cell protease II, a specific product of rat mucosal mast cells. An inactive enantiomer of the substance P antagonist, CP-96,344, had no effect. In contrast, pretreatment with CP-96,345 had no inhibitory effect on the intestinal effects caused by administration of cholera toxin into the ileal loops. From these data, we conclude that the peptide substance P is involved in the secretory and inflammatory effects of toxin A but not of cholera toxin.

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Metadata

Authors
Pothoulakis, C., Castagliuolo, I., LaMont, J. T., Jaffer, A., O'Keane, J. C., Snider, R. M., & Leeman, S. E.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1994-02
Volume
91
Issue
3
Pages
947-951
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.91.3.947
OpenAlex
W2015252693
Cited by
273
References
34
FWCI
12.82
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. https://app.cochat.ai/papers/10.1073/pnas.91.3.947
The paper
Pothoulakis, C., Castagliuolo, I., LaMont, J. T., Jaffer, A., O'Keane, J. C., Snider, R. M., & Leeman, S. E. (1994). CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.3.947

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.