Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells.
Open accessAbstract
Recombinant baculovirus-derived interleukin 6 (IL-6) disrupts the attachment of human ductal breast carcinoma subline ZR-75-1-Tx cells to neighbors and the substratum in culture without inhibiting the proliferation of the cells. The nonadherent cells lack pseudopodia and do not translocate directionally. These findings stand in contrast to the earlier observations in the Ro subline of ZR-75-1 cells in which IL-6 induces cell-cell separation without detachment of the cells from the substratum, with the cells displaying pseudopodia, increased motility, and decreased proliferation. The IL-6-induced ZR-75-1-Tx cell detachment and rounding are reversible by incubation of the treated cells in IL-6-free medium for several days. The distinctive changes induced by IL-6 in ZR-75-1-Ro cells are similarly reversible. Either acidic fibroblast growth factor or phorbol 12-myristate 13-acetate can replace serum as a cofactor in IL-6-induced ZR-75-1-Tx cell detachment. Our findings indicate that genetic changes can occur in breast carcinoma cells that through cytokine action markedly affect cell structure, adhesiveness, and motility.
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- Authors
- Tamm, I., Kikuchi, T., Cardinale, I., & Krueger, J. G.
- Affiliations
- Rockefeller University (US)
- ORCID
- Krueger, J G
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-04-12
- Volume
- 91
- Issue
- 8
- Pages
- 3329-3333
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC43570
- OpenAlex
- W1982289608
- Cited by
- 47
- References
- 22
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 6
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ca054215-05, 5r01ca018608-29)
- National Cancer Institute (CA54215, CA 18608)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- interleukin-6, cell adhesion, breast ductal carcinoma, ZR-75-1 cells, cell detachment, cell motility, pseudopodia, cell-cell adhesion, fibroblast growth factor, phorbol myristate acetate, cytokine signaling
- MeSH terms
- Breast Neoplasms, Cell Adhesion, Cell Division, Female, Humans, Tetradecanoylphorbol Acetate, Tumor Cells, Cultured, Interleukin-6, Fibroblast Growth Factor 1
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