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A family of potassium channel genes related to eag in Drosophila and mammals.
Open accessAbstract
We have identified a conserved family of genes related to Drosophila eag, which encodes a distinct type of voltage-activated K+ channel. Three related genes were recovered in screens of cDNA libraries from Drosophila, mouse, and human tissues. One gene is the mouse counterpart of eag; the other two represent additional subfamilies. The human gene maps to chromosome 7. Family members share at least 47% amino acid identity in their hydrophobic cores and all contain a segment homologous to a cyclic nucleotide-binding domain. Sequence comparisons indicate that members of this family are most closely related to vertebrate cyclic nucleotide-gated cation channels and plant inward-rectifying K+ channels. The existence of another family of K+ channel structural genes further extends the known diversity of K+ channels and has important implications for the structure, function, and evolution of the superfamily of voltage-sensitive ion channels.
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Metadata
- Authors
- Warmke, J. W., & Ganetzky, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-04-12
- Volume
- 91
- Issue
- 8
- Pages
- 3438-3442
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2170592109
- Cited by
- 982
- References
- 0
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Warmke, J. W., & Ganetzky, B. (1994). A family of potassium channel genes related to eag in Drosophila and mammals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.8.3438
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