The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Cellular mechanisms underlying the long QT syndrome
Abstract
QT prolongation is commonly associated with life-threatening torsade de pointes arrhythmias that develop as a consequence of the amplification of electrical heterogeneities intrinsic to the ventricular myocardium. These heterogeneities exist because of differences in the time course of repolarization of the three predominant cell types that make up the ventricular myocardium, giving rise to transmural voltage gradients and a dispersion of repolarization responsible for the inscription of the electrocardiographic T wave. Agents and conditions that reduce net repolarizing current amplify the intrinsic spatial dispersion of repolarization, thus creating the substrate for the development of re-entry. The result is a prolongation of the QT interval, abnormal T waves, and development of polymorphic re-entrant ventricular tachycardia displaying characteristics of torsades de pointes. These conditions also predispose M cells and Purkinje fibers to develop early afterdepolarization-induced extrasystoles, which are thought to trigger episodes of torsades de pointes. Agents that prolong the QT interval but do not increase transmural dispersion of repolarization are not capable of inducing torsades de pointes. The available data suggest that that the principal problem with the long QT syndrome is not long QT intervals but rather the dispersion of repolarization that often accompanies prolongation of the QT interval.
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Cites
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Cited by
Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M., & Zareba, W. (2010) · Circulation · doi:10.1161/circulationaha.109.192704 · Cited by 821
EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias
Aliot, E. M., Stevenson, W. G., Almendral-Garrote, J. M., Bogun, F., Calkins, C. H., Delacretaz, E., Della Bella, P., Hindricks, G., Jaïs, P., Josephson, M. E., et al. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.04.030 · Cited by 770
Long QT syndrome and short QT syndrome
Zareba, W., & Cygankiewicz, I. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.006 · Cited by 96
Classification and mechanism of initiation in patients with congenital long QT syndrome
NODA, T., SHIMIZU, W., SATOMI, K., SUYAMA, K., KURITA, T., AIHARA, N., & KAMAKURA, S. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.08.020 · Cited by 83
Self-citation
Metadata
- Authors
- Antzelevitch, C., & Shimizu, W.
- Venue
- Current Opinion in Cardiology
- Published
- 2002-01
- Volume
- 17
- Issue
- 1
- Pages
- 43-51
- ISSN
- 0268-4705 (ISSN-L)
- OpenAlex
- W2054345442
- Cited by
- 313
- References
- 135
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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