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Inactivation of Bcl-2 by phosphorylation.
Open accessAbstract
The antiapoptosis potential of Bcl-2 protein is well established, but the mechanism of Bcl-2 action is still poorly understood. Using the phosphatase inhibitor okadaic acid or the chemotherapeutic drug taxol, we found that Bcl-2 was phosphorylated in lymphoid cells. Phospho amino acid analysis revealed that Bcl-2 was phosphorylated on serine. Under similar conditions, okadaic acid or taxol treatment led to the induction of apoptosis in these cells. Thus, phosphorylation of Bcl-2 seems to inhibit its ability to interfere with apoptosis. In addition, phosphorylated Bcl-2 can no longer prevent lipid peroxidation as required to protect cells from apoptosis.
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Cited by
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Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
Life, death, and the pursuit of apoptosis.
White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,311
Intrinsic Disorder in Cell-signaling and Cancer-associated Proteins
Iakoucheva, L. M., Brown, C. J., Lawson, J. D., Obradović, Z., & Dunker, A. K. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00969-5 · Cited by 1,214
Reed, J. C. (1998) · Oncogene · doi:10.1038/sj.onc.1202591 · Cited by 1,049
Dhyani, P., Quispe, C., Sharma, E., Bahukhandi, A., Sati, P., Attri, D. C., Szopa, A., Sharifi-Rad, J., Docea, A. O., Mardare, I., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02624-9 · Cited by 483
Metadata
- Authors
- Haldar, S., Jena, N., & Croce, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-05-09
- Volume
- 92
- Issue
- 10
- Pages
- 4507-4511
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996522179
- Cited by
- 731
- References
- 0
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Haldar, S., Jena, N., & Croce, C. M. (1995). Inactivation of Bcl-2 by phosphorylation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.10.4507
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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