Anticancer potential of alkaloids: A key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine
Open accessAbstract
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.
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It has been proposed that most bioactive molecules act as direct antioxidants and do not depend on endogenous intracellular enzymes to exert their primary action by directly reacting with free radicals.
“It has been proposed that most bioactive molecules act as direct antioxidants and they do not have a dependence on endogenous intracellular enzymes to exert their primary action by directly reacting with free radicals [69,121].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [121]
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1 retracted
[Retracted] Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects
Quetglas‐Llabrés, M. M., Quispe, C., Herrera‐Bravo, J., Catarino, M. D., Pereira, O. R., Cardoso, S. M., Dua, K., Chellappan, D. K., Pabreja, K., Satija, S., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8615242 · Cited by 73 · see citing works
Self-citationRetractedMitochondrial reactive oxygen species in cell death signaling
Fleury, C., Mignotte, B., & Vayssière, J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01369-x · Cited by 1,069 · see citing works
Colchicine—Update on mechanisms of action and therapeutic uses
Leung, Y. Y., Hui, L., & Kraus, V. B. (2015) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2015.06.013 · Cited by 967 · see citing works
Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin
Jordan, M. A. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011023354290 · Cited by 776 · see citing works
Inactivation of Bcl-2 by phosphorylation.
Haldar, S., Jena, N., & Croce, C. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4507 · Cited by 744 · see citing works
Sharma, R., Abbasi‐Kangevari, M., Abd-Rabu, R., Abidi, H., Abu-Gharbieh, E., Acuna, J. M., Adhikari, S., Advani, S. M., Afzal, M. S., Meybodi, M. A., et al. (2022) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(22)00044-9 · Cited by 665 · see citing works
Self-citationBest practice in research – Overcoming common challenges in phytopharmacological research
Heinrich, M., Appendino, G., Efferth, T., Fürst, R., Izzo, A. A., Kayser, O., Pezzuto, J. M., & Viljoen, A. M. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112230 · Cited by 619 · see citing works
Colchicine poisoning: the dark side of an ancient drug
Finkelstein, Y., Aks, S. E., Hutson, J. R., et al. (2010) · Clinical Toxicology · doi:10.3109/15563650.2010.495348 · Cited by 591 · see citing works
THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS.
JOHNSON, I. S., Jg, A., Gorman, M., & Jp, B. (1963) · PubMed · Cited by 564 · see citing works
Ann Jordan, M., Thrower, D., & Wilson, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.102.3.401 · Cited by 531 · see citing works
Perez, E. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0366 · Cited by 523 · see citing works
Silverman, J. A., & Deitcher, S. R. (2012) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-012-2042-4 · Cited by 474 · see citing works
ROLE OF CHANCE OBSERVATIONS IN CHEMOTHERAPY: VINCA ROSEA*
Noble, R. L., Beer, C. T., & Cutts, J. H. (1958) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1958.tb54906.x · Cited by 409 · see citing works
Sharifi-Rad, J., Quispe, C., Imran, M., Rauf, A., Nadeem, M., Gondal, T. A., Ahmad, B., Atif, M., Mubarak, M. S., Sytar, O., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3268136 · Cited by 389 · see citing works
Self-citationAlkaloids Isolated from Natural Herbs as the Anticancer Agents
Lu, J., Bao, J., Chen, X.-P., Huang, M., & Wang, Y. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/485042 · Cited by 387 · see citing works
Salehi, B., Quispe, C., Chamkhi, I., Omari, N. E., Balahbib, A., Sharifi‐Rad, J., Bouyahya, A., Akram, M., Iqbal, M., Docea, A. O., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.592654 · Cited by 353 · see citing works
Self-citationVinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead
Martino, E., Casamassima, G., Castiglione, S., Cellupica, E., Pantalone, S., Papagni, F., Rui, M., Siciliano, A. M., & Collina, S. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.06.044 · Cited by 341 · see citing works
Tubulin-Interactive Natural Products as Anticancer Agents
Kingston, D. G. I. (2009) · Journal of Natural Products · doi:10.1021/np800568j · Cited by 327 · see citing works
Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy
Sharifi‐Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 316 · see citing works
Self-citationAntidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don
Tiong, S. H., Looi, C. Y., Hazni, H., Arya, A., Paydar, M., Wong, W. F., Cheah, S., Mustafa, M. R., & Awang, K. (2013) · Molecules · doi:10.3390/molecules18089770 · Cited by 304 · see citing works
Microtubule destabilising agents: far more than just antimitotic anticancer drugs
Bates, D. J. P., & Eastman, A. R. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13126 · Cited by 301 · see citing works
Discovery and engineering of colchicine alkaloid biosynthesis
Nett, R. S., Lau, W., & Sattely, E. S. (2020) · Nature · doi:10.1038/s41586-020-2546-8 · Cited by 297 · see citing works
Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health
Almagro, L., Fernández-Pérez, F., & Pedreño, M. A. (2015) · Molecules · doi:10.3390/molecules20022973 · Cited by 293 · see citing works
Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290 · see citing works
Self-citationA comparative evaluation of some blood sugar lowering agents of plant origin
Chattopadhyay, R. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(99)00095-1 · Cited by 289 · see citing works
Mechanisms of Chemotherapy-Induced Neurotoxicity
Waś, H., Borkowska, A., Bagüés, A., Tu, L., Liu, J. Y. H., Lu, Z., Rudd, J. A., Nurgali, K., & Abalo, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.750507 · Cited by 289 · see citing works
Niel, E., & Scherrmann, J. (2006) · Joint Bone Spine · doi:10.1016/j.jbspin.2006.03.006 · Cited by 286 · see citing works
CANCER CHEMOTHERAPEUTIC AGENTS
Terézhalmy, G. T., Whitmyer, C. C., & Markman, M. (1996) · Dental Clinics of North America · doi:10.1016/s0011-8532(22)00132-x · Cited by 273 · see citing works
Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine
Toso, R. J., Jordan, M. A., Farrell, K., Matsumoto, B., & Wilson, L. (1993) · Biochemistry · doi:10.1021/bi00056a013 · Cited by 244 · see citing works
G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells
Blajeski, A. L., Phan, V., Kottke, T. J., & Kaufmann, S. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13275 · Cited by 232 · see citing works
Groth‐Pedersen, L., Ostenfeld, M. S., Høyer-Hansen, M. H., Nylandsted, J., & Jäättelä, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3520 · Cited by 215 · see citing works
Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation
Nuki, G. (2008) · Current Rheumatology Reports · doi:10.1007/s11926-008-0036-3 · Cited by 200 · see citing works
Overview, prevention and management of chemotherapy extravasation
Kreidieh, F. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i1.87 · Cited by 197 · see citing works
Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts
Wang, S., Zheng, Z., Weng, Y., et al. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.03.005 · Cited by 195 · see citing works
Sharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N. C., Bouyahya, A., Vitalini, S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.600139 · Cited by 183 · see citing works
Self-citationEmerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms
Habli, Z. S., Toumieh, G., Fatfat, M., Rahal, O. N., & Gali‐Muhtasib, H. U. (2017) · Molecules · doi:10.3390/molecules22020250 · Cited by 180 · see citing works
Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics
Škubník, J., Pavlíčková, V. S., Ruml, T., & Rimpelová, S. (2021) · Biology · doi:10.3390/biology10090849 · Cited by 170 · see citing works
Novel Aspects of Natural and Modified Vinca Alkaloids
Duflos, A., Kruczynski, A., & Barret, J.-M. M. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011023354452 · Cited by 166 · see citing works
Preclinical and Clinical Pharmacology of Vinca Alkaloids
Zhou, X., & Rahmani, R. (1992) · Drugs · doi:10.2165/00003495-199200444-00002 · Cited by 163 · see citing works
Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential
Salehi, B., Çapanoğlu, E., Adrar, N., Çatalkaya, G., Shaheen, S., Jaffer, M., Giri, L., Suyal, R., Jugran, A. K., Călina, D. C., et al. (2019) · Molecules · doi:10.3390/molecules24101854 · Cited by 160 · see citing works
Self-citationMoudi, M., Go, R., Yien, C. Y. S., et al. (2013) · PubMed · Cited by 159 · see citing works
Kumar, S., Singh, B., & Singh, R. S. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114647 · Cited by 149 · see citing works
Gregory, R. K., & Smith, I. E. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1203 · Cited by 141 · see citing works
Tumor lysis syndrome: A clinical review
Mirrakhimov, A. E. (2015) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v4.i2.130 · Cited by 136 · see citing works
Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications
Taheri, Y., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Ezzat, S. M., Merghany, R. M., Shaheen, S., Azmi, L., Mishra, A. P., Şener, B., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4024331 · Cited by 133 · see citing works
Self-citationVinflunine: A New Microtubule Inhibitor Agent
Bennouna, J., Delord, J., Campone, M., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2219 · Cited by 128 · see citing works
Butnariu, M., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Singh, L., Aborehab, N. M., Bouyahya, A., Venditti, A., Sen, S., Acharya, K., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8214821 · Cited by 126 · see citing works
Self-citationRobinson, P. C., Terkeltaub, R. A., Pillinger, M. H., Shah, B., Karalis, V. D., Karatza, E., Liew, D. F. L., Imazio, M., Cornel, J. H., Thompson, P. L., et al. (2021) · The American Journal of Medicine · doi:10.1016/j.amjmed.2021.07.025 · Cited by 125 · see citing works
Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective
Salehi, B., Mishra, A. P., Nigam, M., Karazhan, N., Shukla, I., Kiełtyka‐Dadasiewicz, A., SAWICKA, B. H., Głowacka, A., Abu-Darwish, M. S., Tarawneh, A. H., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6884 · Cited by 121 · see citing works
Self-citationEvaluation of wound-healing potential of Catharanthus roseus leaf extract in rats
Nayak, B. S., Anderson, M., & Pereira, L. M. P. (2007) · Fitoterapia · doi:10.1016/j.fitote.2007.06.008 · Cited by 117 · see citing works
New Phenolic Compounds and Antioxidant Potential of Catharanthus roseus
Ferreres, F., Pereira, D. M., Valentão, P., Andrade, P. B., Seabra, R. M., & Sottomayor, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8022723 · Cited by 117 · see citing works
Cancer metabolism: New insights into classic characteristics
Kato, Y., Maeda, T., Suzuki, A., & Baba, Y. (2017) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2017.08.003 · Cited by 117 · see citing works
The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo
Chao, M., Lai, M.-J., Liou, J., Chang, Y., Wang, J.-C., Pan, S., & Teng, C. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0176-7 · Cited by 115 · see citing works
The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model
Docea, A. O., Calina, D., Buga, A. M., Zlatian, O., Paoliello, M. M. B., Mogosanu, G. D., Streba, C. T., Popescu, E. L., Stoica, A. E., Bîrcă, A. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041233 · Cited by 111 · see citing works
Self-citationPereira, D. M., Ferreres, F., Oliveira, J. M. A., Gaspar, L., Faria, J. R. C., Valentão, P., Sottomayor, M., & Andrade, P. B. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.10.008 · Cited by 106 · see citing works
Modifications on the Basic Skeletons of Vinblastine and Vincristine
Keglevich, P., Hazai, L., Kalaus, G., et al. (2012) · Molecules · doi:10.3390/molecules17055893 · Cited by 101 · see citing works
Phytochemicals Derived from Catharanthus roseus and Their Health Benefits
Pham, H. N. T., Vuong, Q. V., Bowyer, M. C., & Scarlett, C. J. (2020) · Technologies · doi:10.3390/technologies8040080 · Cited by 99 · see citing works
Melissa officinalis Extract Inhibits Attachment of Herpes Simplex Virus in vitro
Astani, A., Reichling, J., & Schnitzler, P. (2012) · Chemotherapy · doi:10.1159/000335590 · Cited by 98 · see citing works
Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis
Jain, D., Chaudhary, P., Varshney, N., Razzak, K. S. B., Verma, D., Zahra, T. R. K., Janmeda, P., Sharifi‐Rad, J., Daştan, S. D., Mahmud, S., et al. (2021) · Journal of Oncology · doi:10.1155/2021/5905357 · Cited by 96 · see citing works
Self-citationKoklesová, L., Líšková, A., Samec, M., Qaradakhi, T., Zulli, A., Šmejkal, K., Kajo, K., Jakubı́ková, J., Behzadi, P., Péč, M. J., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00210-5 · Cited by 94 · see citing works
Charpentier, M. S., Whipple, R. A., Vitolo, M. I., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1778 · Cited by 92 · see citing works
Epibatidine: A Promising Natural Alkaloid in Health
Salehi, B., Sestito, S., Rapposelli, S., Peron, G., Calina, D., Sharifi-Rad, M., Sharopov, F., Martins, N., & Sharifi-Rad, J. (2018) · Biomolecules · doi:10.3390/biom9010006 · Cited by 91 · see citing works
Self-citationLin, Z., Kuo, C., Wu, D., et al. (2016) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2015.12.006 · Cited by 90 · see citing works
The Multifarious Link between Cytochrome P450s and Cancer
Alzahrani, A. M., & Rajendran, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3028387 · Cited by 89 · see citing works
Goa, K. L., & Faulds, D. M. (1994) · Drugs & Aging · doi:10.2165/00002512-199405030-00006 · Cited by 87 · see citing works
Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae)
Tiong, S. H., Looi, C. Y., Arya, A., Wong, W. F., Hazni, H., Mustafa, M. R., & Awang, K. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.01.019 · Cited by 83 · see citing works
Case report: fatal poisoning with Colchicum autumnale
Brvar, M., Ploj, T., Koželj, G., et al. (2004) · Critical Care · doi:10.1186/cc2427 · Cited by 80 · see citing works
Hypoglycemic and antihyperglycemic effect of leaves of Vinca rosea linn.
Chattopadhyay, R., Sarkar, S., Ganguly, S., et al. (1991) · PubMed · Cited by 79 · see citing works
Role of Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action
Khan, A. W., Farooq, M., Haseeb, M., & Choi, S. (2022) · Cells · doi:10.3390/cells11081326 · Cited by 76 · see citing works
Novel Therapeutics for the Treatment of Familial Mediterranean Fever: From Colchicine to Biologics
Grattagliano, I., Bonfrate, L., Ruggiero, V., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.148 · Cited by 75 · see citing works
Antimicrobial activity of Catharanthus roseus - a detailed study.
Patil, P. J., & Ghosh, J. S. (2010) · British Journal of Pharmacology and Toxicology · Cited by 74 · see citing works
Parthasarathy, R., Shanmuganathan, R., & Pugazhendhi, A. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.113530 · Cited by 74 · see citing works
Sutoo, S., Maeda, T., Suzuki, A., et al. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09990-1 · Cited by 67 · see citing works
Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer.
Zlatian, O. M., Comanescu, M. V., Roşu, A. F., Roşu, L., Cruce, M., Găman, A. E., Călina, C. D., & Sfredel, V. (2015) · PubMed · Cited by 65 · see citing works
A review of research progress of antitumor drugs based on tubulin targets
Cheng, Z., Lu, X., & Feng, B. (2020) · Translational Cancer Research · doi:10.21037/tcr-20-682 · Cited by 62 · see citing works
Hyssopus Essential Oil: An Update of Its Phytochemistry, Biological Activities, and Safety Profile
Sharifi‐Rad, J., Quispe, C., Kumar, M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8442734 · Cited by 62 · see citing works
Self-citationPathogenesis and treatment options for chemotherapy‐induced alopecia: a systematic review
Rubio-González, B., Juhász, M. L. W., Fortman, J., & Mesinkovska, N. A. (2018) · International Journal of Dermatology · doi:10.1111/ijd.13906 · Cited by 61 · see citing works
Zhang, T., Chen, W., Jiang, X., Liu, L., Wei, K., Du, H., Wang, H., & Li, J. (2018) · Bioscience Reports · doi:10.1042/bsr20181802 · Cited by 61 · see citing works
Single agent vinorelbine in pediatric patients with progressive optic pathway glioma
Cappellano, A. M., Petrilli, A. S., da Silva, N. S., et al. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1652-6 · Cited by 60 · see citing works
Huang, Z., Xu, Y., & Peng, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4222 · Cited by 59 · see citing works
Islam, M. T., Quispe, C., El‐Kersh, D. M., Shill, M. C., Bhardwaj, K., Bhardwaj, P., Sharifi‐Rad, J., Martorell, M., Hossain, R., Al‐Harrasi, A., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6349041 · Cited by 59 · see citing works
Self-citationWang, L., He, H., Di, Y., Zhang, Y., & Hao, X. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.01.060 · Cited by 56 · see citing works
Colchicine in dermatology: A review
Robinson, K., & Chan, J. J. (2018) · Australasian Journal of Dermatology · doi:10.1111/ajd.12795 · Cited by 55 · see citing works
Molecular and cellular stratagem of brain metastases associated with melanoma (Review)
Bugă, A. M., Docea, A. O., Albu, C. V., Mălin, R. D., Branisteanu, D. E., Ianoși, G., Ianoși, S. L., Iordache, A. M., & Călina, D. C. (2019) · Oncology Letters · doi:10.3892/ol.2019.9933 · Cited by 55 · see citing works
Self-citationSertel, S., Fu, Y., Zu, Y., et al. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.12.026 · Cited by 54 · see citing works
An overview of microtubule targeting agents for cancer therapy
Karahalıl, B., Yardım-Akaydin, S., & Baytaş, S. N. (2019) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/aiht-2019-70-3258 · Cited by 54 · see citing works
Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells
Tu, Y., Cheng, S., Zhang, S., Sun, H., & Xu, Z. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1167 · Cited by 52 · see citing works
Bedikian, A. Y., Vardeleon, A., Smith, T., et al. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006288953 · Cited by 52 · see citing works
Kintz, P., Jamey, C., Tracqui, A., et al. (1997) · Journal of Analytical Toxicology · doi:10.1093/jat/21.1.70 · Cited by 52 · see citing works
Cytotoxic Effects of Diterpenoid Alkaloids Against Human Cancer Cells
Wada, K., & Yamashita, H. (2019) · Molecules · doi:10.3390/molecules24122317 · Cited by 49 · see citing works
Vincamine, a safe natural alkaloid, represents a novel anticancer agent
Al-Rashed, S. A., Baker, A., Ahmad, S. S., et al. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104626 · Cited by 49 · see citing works
Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs
Hossain, R., Quispe, C., Saikat, A. S. M., Jain, D., Habib, A., Janmeda, P., Islam, M. T., Radha, Daştan, S. D., Kumar, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/9349897 · Cited by 49 · see citing works
Self-citationTargeted metabolite analysis of Catharanthus roseus and its biological potential
Pereira, D. M., Ferreres, F., Oliveira, J. R., Valentão, P., Andrade, P. B., & Sottomayor, M. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.03.012 · Cited by 48 · see citing works
Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues
Haque, A., Rahman, M. A., Faizi, M. S. H., et al. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867324666170502123639 · Cited by 46 · see citing works
Sani, T. A., Mohammadpour, E., Mohammadi, A., Memariani, T., Yazdi, M. V., Rezaee, R., Călina, D. C., Docea, A. O., Γούμενου, Μ., Etemad, L., et al. (2017) · Cited by 46 · see citing works
Self-citationSingh, B., Kumar, A., Joshi, P., et al. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00406c · Cited by 43 · see citing works
Sharifi-Rad, J., Bahukhandi, A., Dhyani, P., Sati, P., Capanoglu, E., Docea, A. O., Al-Harrasi, A., Dey, A., & Calina, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.664197 · Cited by 43 · see citing works
Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature‐Based Review
Hossain, R., Quispe, C., Herrera‐Bravo, J., Islam, M. S., Sarkar, C. K., Islam, M. T., Martorell, M., Martins, N. A., Al‐Harrasi, A., Al-Rawahi, A. N., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1602437 · Cited by 42 · see citing works
Self-citationAnticancer Effects of Colchicine on Hypopharyngeal Cancer
Cho, J. H., JOO, Y. H., Shin, E. Y., et al. (2017) · Anticancer Research · doi:10.21873/anticanres.12078 · Cited by 41 · see citing works
Microtubule Dynamics Control Tail Retraction in Migrating Vascular Endothelial Cells
Ganguly, A., Yang, H., Zhang, H., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0401 · Cited by 40 · see citing works
Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways
Chen, X., Liu, J., Wang, T., et al. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.01.024 · Cited by 39 · see citing works
Docea, A. O., Mitruț, P., Grigore, D., Pirici, D., Călina, D. C., & Gofiţă, E. (2012) · PubMed · Cited by 38 · see citing works
Self-citationAnticancer Alkaloids of Catharanthus roseus: Transition from Traditional to Modern Medicine
Arora, R., Malhotra, P., Mathur, A., et al. (2010) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/11166_21 · Cited by 38 · see citing works
Sharifi‐Rad, J., Quispe, C., Bouyahya, A., Menyiy, N. E., Omari, N. E., Shahinozzaman, M., Ovey, M. A. H., Koirala, N., Panthi, M., Ertani, A., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6727609 · Cited by 38 · see citing works
Self-citationHappy Accidents: Serendipity in Modern Medical Breakthroughs
(2008) · Radiology · doi:10.1148/radiol.2463072567 · Cited by 38 · see citing works
Schiller, G. J., Damon, L. E., Coutre, S. E., et al. (2018) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2018.0041 · Cited by 35 · see citing works
Accidental Intravenous Colchicine Poisoning
SUSSMAN, J. S., Brozena, S. C., Skop, N., et al. (2004) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200412000-00017 · Cited by 34 · see citing works
Mhaidat, N. M., Al-Zoubi, K., Khabour, O., et al. (2016) · Balkan Journal of Medical Genetics · doi:10.1515/bjmg-2016-0002 · Cited by 34 · see citing works
Gill, J. H., Loadman, P. M., Shnyder, S. D., et al. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400760b · Cited by 33 · see citing works
Shi, Y. X., Chen, L., Li, J., et al. (2010) · Tumor Biology · doi:10.1007/s13277-010-0131-8 · Cited by 32 · see citing works
Anticancer Molecules from Catharanthus roseus
Taher, Z. M., Agouillal, F., R, L. J., et al. (2019) · INDONESIAN JOURNAL OF PHARMACY · doi:10.14499/indonesianjpharm30iss3pp147 · Cited by 32 · see citing works
Joel, S. (1995) · Cancer Treatment Reviews · doi:10.1016/0305-7372(95)90015-2 · Cited by 30 · see citing works
Hassan, A. (2011) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.505 · Cited by 30 · see citing works
Javarappa, K. K., Tsallos, D., & Heckman, C. A. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218777968 · Cited by 30 · see citing works
Khanavi, M., Pourmoslemi, S., Farahanikia, B., et al. (2009) · Pharmaceutical Biology · doi:10.3109/13880200903046187 · Cited by 29 · see citing works
Patel, Y., Vadgama, V. K., Baxi, S., et al. (2011) · PubMed · Cited by 27 · see citing works
Epirubicin or epirubicin and vindesine in advanced breast cancer. A Phase III study
Nielsen, D. L., Dombernowsky, P., Skovsgaard, T., Jensen, J. B., Andersen, E., Engelholm, S., & Hansen, M. (1990) · Annals of Oncology · doi:10.1093/oxfordjournals.annonc.a057748 · Cited by 27 · see citing works
Deciphering the molecular mechanisms of anti-tubulin plant derived drugs
Barbier, P., Tsvetkov, P. O., Breuzard, G., & Devred, F. (2013) · Phytochemistry Reviews · doi:10.1007/s11101-013-9302-8 · Cited by 26 · see citing works
Altinoz, M. A., Özpınar, A., Emekli‐Alturfan, E., et al. (2018) · Journal of Chemotherapy · doi:10.1080/1120009x.2018.1487149 · Cited by 26 · see citing works
Shao, Y., Ding, H., Tang, W., et al. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.05.045 · Cited by 24 · see citing works
Chagas, C. M., & Alisaraie, L. (2019) · ACS Omega · doi:10.1021/acsomega.9b00652 · Cited by 23 · see citing works
Colorectal Cancer and Inflammatory Bowel Disease
Mitruț, P., Docea, A. O., Kamal, A. M., Mitruţ, R., Călina, D. C., Gofiţă, E., Pădureanu, V., Gruia, C. L., & Streba, L. (2016) · InTech eBooks · doi:10.5772/63408 · Cited by 22 · see citing works
Self-citationBakar‐Ates, F., Özmen, N., Kaya‐Sezginer, E., et al. (2018) · Turkish Bulletin of Hygiene and Experimental Biology · doi:10.5505/turkhijyen.2018.22755 · Cited by 18 · see citing works
Colchicine reduces atherosclerotic plaque vulnerability in rabbits
Roubille, F., Merlet, N., Busseuil, D., Ferron, M., Shi, Y., Mihalache-Avram, T., Mecteau, M., Brand, G., Rivas, D., Cossette, M., et al. (2021) · Atherosclerosis Plus · doi:10.1016/j.athplu.2021.08.008 · Cited by 18 · see citing works
Therapeutic use of colchicine and its derivatives: a patent review
Mandhare, A., & Banerjee, P. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1214268 · Cited by 17 · see citing works
Jewkes, J., Pg, H., Tobias, J., et al. (1983) · PubMed · Cited by 15 · see citing works
Lin, Z., Yeh, M., Huang, C., et al. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12374 · Cited by 14 · see citing works
Hsu, F., & Cheng, J. (1992) · Phytotherapy Research · doi:10.1002/ptr.2650060212 · Cited by 12 · see citing works
The importance of developing therapies targeting the biological spectrum of metastatic disease
Zijlstra, A., von Lersner, A. K., Yu, D., et al. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09972-3 · Cited by 12 · see citing works
Chemotherapy-Associated Pulmonary Toxicity—Case Series from a Single Center
Tilak, T., Handa, A., Kumar, K., et al. (2021) · South Asian Journal of Cancer · doi:10.1055/s-0041-1731581 · Cited by 11 · see citing works
Studies on Antioxidant Properties of Catharanthus rosea and Catharanthus alba.
Bhutkar, M. A., & Bhise, S. B. (2011) · Journal of Current Pharma Research · doi:10.33786/jcpr.2011.v01i04.007 · Cited by 9 · see citing works
Valerio, M. R., Spadaro, P., Arcanà, C., et al. (2021) · Future Science OA · doi:10.2144/fsoa-2020-0095 · Cited by 9 · see citing works
Evaluation of intraperitoneal vincristine in malignant peritoneal effusion.
Bairy, K. L., Sanath, S., Jagetia, G. C., et al. (2003) · PubMed · Cited by 8 · see citing works
Vincristine: Beyond on anticancer treatment
Tiwari, D., & Tiwari, M. (2020) · International Journal of Pharmacognosy and Life Science · doi:10.33545/27072827.2020.v1.i2a.17 · Cited by 6 · see citing works
Afsahul, K. M., & Anjum, F. (2020) · International Journal of Unani and Integrative Medicine · doi:10.33545/2616454x.2020.v4.i1a.115 · Cited by 6 · see citing works
Smith, I. E., Hedley, D. W., Coombes, R. C., et al. (1980) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(80)80011-9 · Cited by 5 · see citing works
Pernot, B., Gyan, E., Maillot, F., Hodges, P. B., Daneshpouy, M. E., & Ferreira-Maldent, N. (2018) · Medicine · doi:10.1097/md.0000000000013228 · Cited by 4 · see citing works
Selective COX-2 Inhibitor (Rofecoxib) Inhibits Vinorelbine Cytotoxicity in C6 Glioma Cells In Vitro
Tuna, S., Altinoz, M. A., Karasu, A., et al. (2009) · The Open Pathology Journal · doi:10.2174/1874375700903010022 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 12
- [7]Wild C Weiderpass E Stewart BW World cancer report: cancer research for cancer prevention 2020 Lyon IARC Press 39432694
- [37]Webb LJ. Guide to the medicinal and poisonous plants of Queensland. Bulletin of the Council for Scientific and Industrial Research, Australia. 1948(232).
- [42]Nisar A Mamat AS Hatim MI Aslam MS Syarhabil M An updated review on Catharanthus roseus: phytochemical and pharmacological analysis Indian Res J Pharm Sci 2016 3 2 631 653
- [44]Nguywen VD. List of simple drugs and medicinal plants of value in Vietnam. In: Proc seminar of the use of medicinal plants in healthcare Tokyo: 1977; 1977. pp. 13–17.
- [46]Gajalakshmi S Vijayalakshmi S Devi RV Pharmacological activities of Catharanthus roseus: a perspective review Int J Pharm Bio Sci 2013 4 2 431 439
- [48]Farnsworth N. Plants and modern medicine: where science and folklore Meets. In: World Health Forum: 1985; 1985. pp. 76–80.
- [54]Mishra JN Verma NK A brief study on Catharanthus roseus: a review Intern J Res Pharm Pharm Sci 2017 2 2 20 23
- [76]Arora RD, Menezes RG. Vinca alkaloid toxicity. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. 32491774
- [92]Allamsetty J, Pedada SP, Pedada N, Kolli D. A basic review on Vinca rosea. Int J Pharmacogn Chem. 2020:31–36.
- [93]Retna AM Ethalsa P A review of the taxonomy, ethnobotany, chemistry and pharmacology of Catharanthus roseus (Apocyanaceae) Int J Eng Res Technol 2013 2 10 3899 3912
- [107]Kumar A Vincristine and vinblastine: a review IJMPS 2016 6 23 30
- [152]Kumar S Singh B Singh R Catharanthus roseus (L.) G. Don: a review of its ethnobotany, phytochemistry, ethnopharmacology and toxicities J Ethnopharmacol 2022 284 114647 10.1016/j.jep.2021.114647 34562562 · DOI
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Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Self-citationKitic, D., Miladinovic, B., Randjelovic, M., Szopa, A., Sharifi-Rad, J., Calina, D., & Seidel, V. (2022) · Plants · doi:10.3390/plants11141885 · Cited by 96 · see citing works
Self-citationMyricetin: Targeting signaling networks in cancer and its implication in chemotherapy
Javed, Z., Khan, K., Herrera-Bravo, J., Naeem, S., Iqbal, M. J., Raza, Q., Sadia, H., Raza, S., Bhinder, M., Calina, D., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02663-2 · Cited by 93 · see citing works
Self-citationSharifi-Rad, J., Quispe, C., Turgumbayeva, A., Mertdinç, Z., Tütüncü, S., Aydar, E. F., Özçelik, B., Anna, S.-W., Mariola, S., Koziróg, A., et al. (2023) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2022-0076 · Cited by 39 · see citing works
Self-citationAsensio‐Juárez, G., Pérez‐Díaz, R., Ramos‐Solano, H., Garrido‐Casado, M., Talayero, V. C., & Vicente‐Manzanares, M. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70333
- Authors
- Dhyani, P., Quispe, C., Sharma, E., Bahukhandi, A., Sati, P., Attri, D. C., Szopa, A., Sharifi-Rad, J., Docea, A. O., Mardare, I., Calina, D., & Cho, W. C.
- Affiliations
- Kumaun University (IN)
- Arturo Prat University (CL)
- Guru Nanak Dev University (IN)
- G.B. Pant Institute of Himalayan Environment and Development (IN)
- Graphic Era University (IN)
- Jagiellonian University (PL)
- University of Medicine and Pharmacy of Craiova (RO)
- Carol Davila University of Medicine and Pharmacy (RO)
- Queen Elizabeth Hospital (CN)
- Corresponding author
- Cho, William C.
- ORCID
- Venue
- Cancer Cell International
- Published
- 2022-06-02
- Volume
- 22
- Issue
- 1
- Pages
- 206-206
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC9161525
- OpenAlex
- W4281836397
- Cited by
- 483
- References
- 138
- Citations by year
- 2026: 83 · 2025: 133 · 2024: 135 · 2023: 102 · 2022: 30
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- antitumor alkaloids, colchicine, vinblastine, vincristine, vindesine, vinorelbine, vincamine, vinca alkaloids, anticancer mechanism, plant secondary metabolites, chemoresistance, traditional medicine, cancer prevention
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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