Cited by 483Alkaloids: synthesis and pharmacologyBerberine and alkaloids researchPhytochemical Studies and Bioactivities

Anticancer potential of alkaloids: A key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Open access
Dhyani, Praveen, Quispe, Cristina, Sharma, Eshita, Bahukhandi, Amit, Sati, Priyanka, Attri, Dharam Chand, Szopa, Agnieszka, Sharifi-Rad, Javad +4 more·2022·Cancer Cell International

Abstract

Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

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Authors
Dhyani, P., Quispe, C., Sharma, E., Bahukhandi, A., Sati, P., Attri, D. C., Szopa, A., Sharifi-Rad, J., Docea, A. O., Mardare, I., Calina, D., & Cho, W. C.
Affiliations
  • Kumaun University (IN)
  • Arturo Prat University (CL)
  • Guru Nanak Dev University (IN)
  • G.B. Pant Institute of Himalayan Environment and Development (IN)
  • Graphic Era University (IN)
  • Jagiellonian University (PL)
  • University of Medicine and Pharmacy of Craiova (RO)
  • Carol Davila University of Medicine and Pharmacy (RO)
  • Queen Elizabeth Hospital (CN)
Corresponding author
Cho, William C.
Venue
Cancer Cell International
Published
2022-06-02
Volume
22
Issue
1
Pages
206-206
ISSN
1475-2867 (ISSN-L)
OpenAlex
W4281836397
Cited by
483
References
138
Citations by year
2026: 83 · 2025: 133 · 2024: 135 · 2023: 102 · 2022: 30
FWCI
17.32
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
  • Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Keywords
antitumor alkaloids, colchicine, vinblastine, vincristine, vindesine, vinorelbine, vincamine, vinca alkaloids, anticancer mechanism, plant secondary metabolites, chemoresistance, traditional medicine, cancer prevention

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