The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion.
Open accessAbstract
Chlamydia trachomatis undergoes its entire life cycle within an uncharacterized intracellular vesicle that does not fuse with lysosomes. We used a fluorescent Golgi-specific probe, (N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]) aminocaproylsphingosine (C6-NBD-Cer), in conjunction with conventional fluorescence or confocal microscopy to identify interactions between the Golgi apparatus and the chlamydial inclusion. We observed not only a close physical association between the Golgi apparatus and the chlamydial inclusion but the eventual presence of a metabolite of this fluorescent probe associated with the chlamydiae themselves. Sphingomyelin, endogenously synthesized from C6-NBD-Cer, was specifically transported to the inclusion and incorporated into the cell wall of the intracellular chlamydiae. Incorporation of the fluorescent sphingolipid by chlamydiae was inhibited by brefeldin A. Chlamydiae therefore occupy a vesicle distal to the Golgi apparatus that receives anterograde vesicular traffic from the Golgi normally bound for the plasma membrane. Collectively, the data suggest that the chlamydial inclusion may represent a unique compartment within the trans-Golgi network.
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Cites
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Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens
Finlay, B. B., & Cossart, P. (1997) · Science · doi:10.1126/science.276.5313.718 · Cited by 746
Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., Starnbach, M. N., & Sabatini, D. M. (2013) · Nature Cell Biology · doi:10.1038/ncb2865 · Cited by 169
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Vromman, F., & Subtil, A. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.11.003 · Cited by 42
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Herweg, J., & Rudel, T. (2016) · The FEBS Journal · doi:10.1111/febs.13609 · Cited by 39
Metadata
- Authors
- Hackstadt, T., Scidmore, M. A., & Rockey, D. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-05-23
- Volume
- 92
- Issue
- 11
- Pages
- 4877-4881
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1985947029
- Cited by
- 354
- References
- 18
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Hackstadt, T., Scidmore, M. A., & Rockey, D. D. (1995). Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.11.4877
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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