The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Capturing genes encoding membrane and secreted proteins important for mouse development.
Open accessAbstract
A strategy based on the gene trap was developed to prescreen mouse embryonic stem cells for insertional mutations in genes encoding secreted and membrane-spanning proteins. The "secretory trap" relies on capturing the N-terminal signal sequence of an endogenous gene to generate an active beta-galactosidase fusion protein. Insertions were found in a cadherin gene, an unc6-related laminin (netrin) gene, the sek receptor tyrosine kinase gene, and genes encoding two receptor-linked protein-tyrosine phosphatases, LAR and PTP kappa. Analysis of homozygous mice carrying insertions in LAR and PTP kappa showed that both genes were effectively disrupted, but neither was essential for normal embryonic development.
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Cites
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UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans
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Cited by
A conditional knockout resource for the genome-wide study of mouse gene function
Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature · doi:10.1038/nature10163 · Cited by 1,708
Self-citationTHE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT
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Ambra1 regulates autophagy and development of the nervous system
Maria Fimia, G., Stoykova, A., Romagnoli, A., Giunta, L., Di Bartolomeo, S., Nardacci, R., Corazzari, M., Fuoco, C., Ucar, A., Schwartz, P., et al. (2007) · Nature · doi:10.1038/nature05925 · Cited by 1,048
Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor
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Branda, C. S., & Dymecki, S. M. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00399-x · Cited by 867
Metadata
- Authors
- Skarnes, W. C., Moss, J. E., Hurtley, S. M., & Beddington, R. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-07-03
- Volume
- 92
- Issue
- 14
- Pages
- 6592-6596
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035912798
- Cited by
- 318
- References
- 21
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Skarnes, W. C., Moss, J. E., Hurtley, S. M., & Beddington, R. S. (1995). Capturing genes encoding membrane and secreted proteins important for mouse development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.14.6592
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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