Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.
Open accessAbstract
Human melanoma cells can process the MAGE-1 gene product and present the processed nonapeptide EADPTGHSY on their major histocompatibility complex class I molecules, HLA-A1, as a determinant for cytolytic T lymphocytes (CTLs). Considering that autologous antigen presenting cells (APCs) pulsed with the synthetic nonapeptide might, therefore, be immunogenic, melanoma patients whose tumor cells express the MAGE-1 gene and who are HLA-A1+ were immunized with a vaccine made of cultured autologous APCs pulsed with the synthetic nonapeptide. Analyses of the nature of the in vivo host immune response to the vaccine revealed that the peptide-pulsed APCs are capable of inducing autologous melanoma-reactive and the nonapeptide-specific CTLs in situ at the immunization site and at distant metastatic disease sites.
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Both the T cell pools of healthy individuals and cancer patients contain T cells that can identify KRAS mutation; after vaccination those T cells can be selectively expanded in tumor patients.
“Both the T cell pools of healthy individuals and cancer patients contain T cells that can identify KRAS mutation. After vaccination those T cells can be selectively expanded in tumor patients.”
From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [84]
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- Authors
- Mukherji, B., Chakraborty, N. G., Yamasaki, S., Okino, T., Yamase, H., Sporn, J. R., Kurtzman, S. K., Ergin, M. T., Ozols, J., & Meehan, J.
- Affiliations
- University of Connecticut (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1995-08-15
- Volume
- 92
- Issue
- 17
- Pages
- 8078-8082
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC41290
- OpenAlex
- W2049364599
- Cited by
- 326
- References
- 14
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 1
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (RR 06192)
- National Cancer Institute (CA 61398)
- National Center for Research Resources (M01RR006192, MO1 RR06192)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- melanoma, MAGE-1, cytotoxic T lymphocytes, antigen-presenting cells, HLA-A1, tumor-specific antigens, immunotherapy, metastatic melanoma
- MeSH terms
- Amino Acid Sequence, Antigen-Presenting Cells, Antigens, Neoplasm, Cell Line, Humans, Immunotherapy, Melanoma, Molecular Sequence Data, Neoplasm Proteins, Peptide Fragments, Recombinant Proteins, T-Lymphocytes, Cytotoxic, Tumor Cells, Cultured, Vaccines, Synthetic, HLA-A1 Antigen, Gene Expression, Immunophenotyping, Polymerase Chain Reaction, Granulocyte-Macrophage Colony-Stimulating Factor, Lymphocytes, Tumor-Infiltrating, Melanoma-Specific Antigens
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