The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.
Open accessAbstract
Guinea pig eotaxin is a recently described member of the Cys-Cys family of chemokines and is involved in a guinea pig model of asthma. To determine whether eotaxin is a distinctive member of this family and to understand its physiologic role, we have cloned the mouse eotaxin gene and determined its structure and aspects of its biologic function. The sequence relationship between the mouse and guinea pig genes indicates that eotaxin is indeed a distinct member of the chemokine family. Moreover, murine eotaxin maps to a region of mouse chromosome 11 that encodes other Cys-Cys chemokines. In addition, recombinant murine eotaxin protein has direct chemoattractant properties for eosinophils. The eotaxin gene is widely (but not ubiquitously) expressed in normal mice and is strongly induced in cultured endothelial cells in response to interferon gamma. Eotaxin is also induced locally in response to the transplantation of interleukin 4-secreting tumor cells, indicating that it likely contributes to the eosinophil recruitment and antitumor effect of interleukin 4. Such responses suggest that eotaxin may be involved in multiple inflammatory states.
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Biologic activities of the murine beta -chemokine TCA3.
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Cited by
Gouon-Evans, V., Lin, E. Y., & Pollard, J. W. (2002) · Breast Cancer Research · doi:10.1186/bcr441 · Cited by 217
Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9759735 · Cited by 190
Huang, Z., Zhong, L., Lee, J. T. H., Zhang, J., Wu, D., Geng, L., Wang, Y., Wong, C.-M., & Xu, A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.003 · Cited by 147
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Emerging Roles for Eosinophils in the Tumor Microenvironment
Reichman, H., Karo-Atar, D., & Munitz, A. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.002 · Cited by 116
Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness
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Metadata
- Authors
- Rothenberg, M. E., Luster, A. D., & Leder, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-09-12
- Volume
- 92
- Issue
- 19
- Pages
- 8960-8964
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057125179
- Cited by
- 345
- References
- 1
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- green
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