The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Telomerase activity in normal and malignant hematopoietic cells
Abstract
Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain telomerase activity detectable by a PCR-based assay. Telomerase was also detectable in nonmalignant bone marrow and peripheral blood leukocytes from normal donors, including fractions enriched for granulocytes, T lymphocytes, and monocytes/B cells. Semiquantitative comparison revealed considerable overlap between telomerase activities in samples from normal subjects and leukemia patients, confounding evaluation of the role of telomerase in this disease. These data indicate that human telomerase is not restricted to immortal cells and suggest that the somatic expression of this enzyme may be more widespread than was previously inferred from the decline of human telomeres.
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“Telomerase is primarily active in proliferating cells, hematopoietic stem cells, and rapidly renewing cells [114,115,116].”
From Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges (2024) · cites this paper as [115]
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Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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Telomeres shorten during ageing of human fibroblasts
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Cited by
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
Metadata
- Authors
- Broccoli, D., Young, J. W., & de Lange, T.
- Affiliations
- Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1995-09-26
- Volume
- 92
- Issue
- 20
- Pages
- 9082-9086
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 567
- References
- 9
- Language
- en
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- Broccoli, D., Young, J. W., & de Lange, T. (1995). Telomerase activity in normal and malignant hematopoietic cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.20.9082
