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Cited by 567

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Telomerase activity in normal and malignant hematopoietic cells

Broccoli, D, Young, J W, de Lange, T·1995·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.92.20.9082
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Abstract

Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain telomerase activity detectable by a PCR-based assay. Telomerase was also detectable in nonmalignant bone marrow and peripheral blood leukocytes from normal donors, including fractions enriched for granulocytes, T lymphocytes, and monocytes/B cells. Semiquantitative comparison revealed considerable overlap between telomerase activities in samples from normal subjects and leukemia patients, confounding evaluation of the role of telomerase in this disease. These data indicate that human telomerase is not restricted to immortal cells and suggest that the somatic expression of this enzyme may be more widespread than was previously inferred from the decline of human telomeres.

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Show all 9 references

Research works printed but not linked: 7

  1. [7]Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B. & Lansdorp, P. M. (1994) Proc. Natl. Acad. Sci. USA 91, 9857-9860.
  2. [10]Blackburn, E. (1983) in Reverse Transcriptase, eds. Gesteland, R. & Atkins, J. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 557–576.
  3. [13]Allsopp, R., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E., Futcher, B., Greider, C. W. & Harley, C. B. (1992) Proc. Natl. Acad. Sci. USA 89, 10114–10118.
  4. [17]de Lange, T. (1994) Proc. Natl. Acad. Sci. USA 91, 2882–2885.
  5. [19]de Lange, T. (1995) in Telomeres, eds. Blackburn, E. H. & Greider, C. W. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 265-293.
  6. [20]Counter, C. M., Hirte, H. W., Bacchetti, S. & Harley, C. (1994) Proc. Natl. Acad. Sci. USA 91, 2900–2904.
  7. [23]Zakian, V. A. (1995) in Telomeres, eds. Blackburn, E. H. & Greider, C. W. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 107-137.

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Metadata

Authors
Broccoli, D., Young, J. W., & de Lange, T.
Affiliations
Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1995-09-26
Volume
92
Issue
20
Pages
9082-9086
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.92.20.9082
Cited by
567
References
9
Language
en

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