The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.
Open accessAbstract
Transgenic Caenorhabditis elegans nematodes have been engineered to express potentially amyloidic human proteins. These animals contain constructs in which the muscle-specific unc-54 promoter/enhancer of C. elegans drives the expression of the appropriate coding regions derived from human cDNA clones. Animals containing constructs expressing the 42-amino acid beta-amyloid peptide (derived from human amyloid precursor protein cDNA) produce muscle-specific deposits immunoreactive with anti-beta-amyloid polyclonal and monoclonal antibodies. A subset of these deposits also bind the amyloid-specific dye thioflavin S, indicating that these deposits have the tinctural characteristics of classic amyloid. Co-expression of beta-peptide and transthyretin, a protein implicated in preventing the formation of insoluble beta-amyloid, leads to a dramatic reduction in the number of dye-reactive deposits. These results suggest that this invertebrate model may be useful for in vivo investigation of factors that modulate amyloid formation.
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Metadata
- Authors
- Link, C. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-09-26
- Volume
- 92
- Issue
- 20
- Pages
- 9368-9372
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975595547
- Cited by
- 687
- References
- 41
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Link, C. D. (1995). Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.20.9368
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
