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Cited by 668

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas.

Open access
Suzich, J A, Ghim, S J, Palmer-Hill, F J, White, W I, Tamura, J K, Bell, J A, Newsome, J A, Jenson, A B, Schlegel, R·1995·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.92.25.11553
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Abstract

Infection of mucosal epithelium by papillomaviruses is responsible for the induction of genital and oral warts and plays a critical role in the development of human cervical and oropharyngeal cancer. We have employed a canine model to develop a systemic vaccine that completely protects against experimentally induced oral mucosal papillomas. The major capsid protein, L1, of canine oral papillomavirus (COPV) was expressed in Sf9 insect cells in native conformation. L1 protein, which self-assembled into virus-like particles, was purified on CsCl gradients and injected intradermally into the foot pad of beagles. Vaccinated animals developed circulating antibodies against COPV and became completely resistant to experimental challenge with COPV. Successful immunization was strictly dependent upon native L1 protein conformation and L1 type. Partial protection was achieved with as little as 0.125 ng of L1 protein, and adjuvants appeared useful for prolonging the host immune response. Serum immunoglobulins passively transferred from COPV L1-immunized beagles to naive beagles conferred protection from experimental infection with COPV. Our results indicate the feasibility of developing a human vaccine to prevent mucosal papillomas, which can progress to malignancy.

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Crossref · 10.1073/pnas.92.25.11553

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Metadata

Authors
Suzich, J. A., Ghim, S. J., Palmer-Hill, F. J., White, W. I., Tamura, J. K., Bell, J. A., Newsome, J. A., Jenson, A. B., & Schlegel, R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1995-12-05
Volume
92
Issue
25
Pages
11553-11557
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.92.25.11553
OpenAlex
W2049095033
Cited by
668
References
16
FWCI
17.55
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. https://app.cochat.ai/papers/10.1073/pnas.92.25.11553
The paper
Suzich, J. A., Ghim, S. J., Palmer-Hill, F. J., White, W. I., Tamura, J. K., Bell, J. A., Newsome, J. A., Jenson, A. B., & Schlegel, R. (1995). Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.25.11553

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.