The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Viruses in Human Cancers
Abstract
Viruses may contribute to the development of human tumors by different mechanisms: indirectly by inducing immunosuppression or by modifying the host cell genome without persistence of viral DNA; directly by inducing oncoproteins or by altering the expression of host cell proteins at the site of viral DNA integration. Human cancers associated with papillomavirus, hepatitis B virus, Epstein-Barr virus, and human T cell leukemia-lymphoma virus infections are responsible for approximately 15 percent of the worldwide cancer incidence. Cancer of the cervix and hepatocellular carcinoma account for about 80 percent of virus-linked cancers. Because experimental and epidemiologic data imply a causative role for viruses, particularly in cervical and liver cancer, viruses must be thought of as the second most important risk factor for cancer development in humans, exceeded only by tobacco consumption.
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Cites
Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., & Gallo, R. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7415 · Cited by 5,043
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Yoshida, M., Miyoshi, I., & Hinuma, Y. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.2031 · Cited by 2,169
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation
Cann, A. J., Rosenblatt, J. D., Wachsman, W., Shah, N. P., & Chen, I. S. Y. (1985) · Nature · doi:10.1038/318571a0 · Cited by 208
p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.
Kiyokawa, T., Seiki, M., Iwashita, S., Imagawa, K., Shimizu, F., & Yoshida, M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8359 · Cited by 169
Cited by
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981
Suzich, J. A., Ghim, S. J., Palmer-Hill, F. J., White, W. I., Tamura, J. K., Bell, J. A., Newsome, J. A., Jenson, A. B., & Schlegel, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11553 · Cited by 668
Duensing, S., Lee, L. Y., Duensing, A., Basile, J., Piboonniyom, S.-O., Gonzalez, S., Crum, C. P., & Münger, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170093297 · Cited by 397
Establishment of human papillomavirus infection requires cell cycle progression
Pyeon, D., Pearce, S. M., Lank, S. M., Ahlquist, P., & Lambert, P. F. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000318 · Cited by 348
Metadata
- Authors
- zur Hausen, H.
- Venue
- Science
- Published
- 1991-11-22
- Volume
- 254
- Issue
- 5035
- Pages
- 1167-1173
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2143080883
- Cited by
- 784
- References
- 6
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- zur Hausen, H. (1991). Viruses in Human Cancers. Science. https://doi.org/10.1126/science.1659743
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
