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Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase.
Open accessAbstract
A cDNA encoding a signal transduction protein with a Src homology 2 (SH2) domain and a tyrosine phosphorylation site was cloned from a rat lymph node cDNA library. This protein, which we designate Lnk, has a calculated molecular weight of 33,988. When T lymphocytes were activated by antibody-mediated crosslinking of the T-cell receptor and CD4, Lnk became tyrosine phosphorylated. In activated T lymphocytes, phospholipase C gamma 1, phosphatidylinositol 3-kinase, and Grb-2 coimmunoprecipitated with Lnk. Our results suggest that Lnk becomes tyrosine phosphorylated and links the immediate tyrosine phosphorylation signals of the TCR to the distal phosphatidylinositol 3-kinase, phospholipase C gamma 1 and Ras signaling pathways through its multifunctional tyrosine phosphorylation site.
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Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251
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Marengère, L. E. M., Waterhouse, P., Duncan, G. S., Mittrücker, H.-W., Feng, G.-S., & Mak, T. W. (1996) · Science · doi:10.1126/science.272.5265.1170 · Cited by 551
Croxtall, J. D., Choudhury, Q., & Flower, R. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703272 · Cited by 332
The complexity of signaling pathways activated by the BCR
DeFranco, A. L. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80074-x · Cited by 251
Metadata
- Authors
- Huang, X., Li, Y., Tanaka, K., Moore, K. G., & Hayashi, J. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-12-05
- Volume
- 92
- Issue
- 25
- Pages
- 11618-11622
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2095222091
- Cited by
- 158
- References
- 2
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, X., Li, Y., Tanaka, K., Moore, K. G., & Hayashi, J. I. (1995). Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.25.11618
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