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The complexity of signaling pathways activated by the BCR

DeFranco, Anthony L·1997·Current Opinion in Immunology
DOI 10.1016/s0952-7915(97)80074-x
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Abstract

Cross-linking of the B cell antigen receptor (BCR) leads to the activation of three types of intracellular protein tyrosine kinases. These tyrosine kinases then phosphorylate signaling components to activate a variety of signaling reactions, including phosphatidylinositol 4,5-bisphosphate hydrolysis, Ras activation, and phosphatidylinositol 3-kinase activation. Each of these signaling reactions, and also the signaling molecules Vav and HS1, appears to be important for at least some of the many types of B cell responses to antigen. The complexity of BCR signaling reactions may be required to allow the B cell to respond in a number of distinct ways to antigen (proliferation, survival, apoptosis, maturational arrest, etc.) depending on the maturation state of the B cell, the location in the body, the physical nature of the antigen, and the possible presence of the antigen in complex with antibody or complement components.

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Metadata

Authors
DeFranco, A. L.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
1997-06
Volume
9
Issue
3
Pages
296-308
ISSN
0952-7915
DOI
10.1016/s0952-7915(97)80074-x
Cited by
251
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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