The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens.
Open accessAbstract
The presentation of antigenic peptides by major histocompatibility complex (MHC) class II molecules to CD4+ T cells is critical to the function of the immune system. In this study, we have utilized the sorting signal of the lysosomal-associated membrane protein LAMP-1 to target a model antigen, human papillomavirus 16 E7 (HPV-16 E7), into the endosomal and lysosomal compartments. The LAMP-1 sorting signal reroutes the antigen into the MHC class II processing pathway, resulting in enhanced presentation to CD4+ cells in vitro. In vivo immunization experiments in mice demonstrated that vaccinia containing the chimeric E7/LAMP-1 gene generated greater E7-specific lymphoproliferative activity, antibody titers, and cytotoxic T-lymphocyte activities than vaccinia containing the wild-type HPV-16 E7 gene. These results suggest that specific targeting of an antigen to the endosomal and lysosomal compartments enhances MHC class II presentation and vaccine potency.
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The Central Role of CD4+ T Cells in the Antitumor Immune Response
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mRNA therapeutics in cancer immunotherapy
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Metadata
- Authors
- Wu, T. C., Guarnieri, F. G., Staveley-O'Carroll, K. F., Viscidi, R. P., Levitsky, H. I., Hedrick, L., Cho, K. R., August, J. T., & Pardoll, D. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-12-05
- Volume
- 92
- Issue
- 25
- Pages
- 11671-11675
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2092438678
- Cited by
- 344
- References
- 46
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, T. C., Guarnieri, F. G., Staveley-O'Carroll, K. F., Viscidi, R. P., Levitsky, H. I., Hedrick, L., Cho, K. R., August, J. T., & Pardoll, D. M. (1995). Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.25.11671
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
