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IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.
Abstract
Five rat monoclonal antibodies have been derived that express specificities for determinants present on the molecular complex bearing the Lyt 2 antigen. SDS-polyacrylamide gel electrophoresis of 125I-labeled polypeptides precipitated by each of these antibodies reveal 3 components (150,000, 75,000, and 33,000 daltons), and 2 components (44,000 and 33,000 daltons) when analyzed under nonreducing and reducing conditions, respectively. Two of these antibodies are IgG and are specific for the Lyt 2.2 determinant; the other 3 are IgM and react with determinants other than Lyt 2.2, which are nonpolymorphic. Each of the 5 antibodies can block the cytolytic activities of 5-day MLC cells or of cloned cytolytic T cells in the absence of C. Treatment of responding spleen cells with any of these antibodies and C inhibits the generation of cytolytic activity in MLC.
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Cited by
Fearon, E. R., Pardoll, D. M., Itaya, T., Golumbek, P., Levitsky, H. I., Simons, J. W., Karasuyama, H., Vogelstein, B., & Frost, P. (1990) · Cell · doi:10.1016/0092-8674(90)90591-2 · Cited by 916
BAIN, G. (1994) · Cell · doi:10.1016/0092-8674(94)90077-9 · Cited by 635
Immunotherapy of malignancy by in vivo gene transfer into tumors.
Plautz, G. E., Yang, Z. Y., Wu, B. Y., Gao, X., Huang, L., & Nabel, G. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4645 · Cited by 317
Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo
Farrell, H. E., Vally, H., Lynch, D. M., Fleming, P., Shellam, G. R., Scalzo, A. A., & Davis-Poynter, N. J. (1997) · Nature · doi:10.1038/386510a0 · Cited by 306
T-Cell Subsets Required for Intravesical BCG Immunotherapy for Bladder Cancer
Ratliff, T. L., Ritchey, J. K., Yuan, J. J. J., Andriole, G. L., & Catalona, W. J. (1993) · Journal of Urology · doi:10.1016/s0022-5347(17)35678-1 · Cited by 283
Metadata
- Authors
- Sarmiento, M., Glasebrook, A. L., & Fitch, F. W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-12-01
- Volume
- 125
- Issue
- 6
- Pages
- 2665-2672
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1612135387
- Cited by
- 802
- References
- 0
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. https://app.cochat.ai/papers/10.4049/jimmunol.125.6.2665
- The paper
- Sarmiento, M., Glasebrook, A. L., & Fitch, F. W. (1980). IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. The Journal of Immunology. https://doi.org/10.4049/jimmunol.125.6.2665
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