The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cell density control of staphylococcal virulence mediated by an octapeptide pheromone.
Open accessAbstract
Some bacterial pathogens elaborate and secrete virulence factors in response to environmental signals, others in response to a specific host product, and still others in response to no discernible cue. In this study, we have demonstrated that the synthesis of Staphylococcus aureus virulence factors is controlled by a density-sensing system that utilizes an octapeptide produced by the organism itself. The octapeptide activates expression of the agr locus, a global regulator of the virulence response. This response involves the reciprocal regulation of genes encoding surface proteins and those encoding secreted virulence factors. As cells enter the postexponential phase, surface protein genes are repressed by agr and secretory protein genes are subsequently activated. The intracellular agr effector is a regulatory RNA, RNAIII, whose transcription is activated by an agr-encoded signal transduction system for which the octapeptide is the ligand.
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Cites
Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers.
Hillenkamp, F., Karas, M., Beavis, R. C., & Chait, B. T. (1991) · Analytical Chemistry · doi:10.1021/ac00024a716 · Cited by 1,930
Self-citation
Cited by
Navarre, W. W., & Schneewind, O. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.174-229.1999 · Cited by 1,391
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Listening in on bacteria: acyl-homoserine lactone signalling
Fuqua, C., & Greenberg, E. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm907 · Cited by 1,079
Thinking about Bacterial Populations as Multicellular Organisms
Shapiro, J. A. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.81 · Cited by 876
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases
Mascher, T., Helmann, J. D., & Unden, G. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-06 · Cited by 721
Metadata
- Authors
- Ji, G., Beavis, R. C., & Novick, R. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-12-19
- Volume
- 92
- Issue
- 26
- Pages
- 12055-12059
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2071123327
- Cited by
- 664
- References
- 1
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Ji, G., Beavis, R. C., & Novick, R. P. (1995). Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.26.12055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
