The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Intron phase correlations and the evolution of the intron/exon structure of genes.
Open accessAbstract
Two issues in the evolution of the intron/exon structure of genes are the role of exon shuffling and the origin of introns. Using a large data base of eukaryotic intron-containing genes, we have found that there are correlations between intron phases leading to an excess of symmetric exons and symmetric exon sets. We interpret these excesses as manifestations of exon shuffling and make a conservative estimate that at least 19% of the exons in the data base were involved in exon shuffling, suggesting an important role for exon shuffling in evolution. Furthermore, these excesses of symmetric exons appear also in those regions of eukaryotic genes that are homologous to prokaryotic genes: the ancient conserved regions. This last fact cannot be explained in terms of the insertional theory of introns but rather supports the concept that some of the introns were ancient, the exon theory of genes.
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Self-citation2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans
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Self-citationIntron phylogeny: a new hypothesis
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Self-citationIntron‐dependent evolution: Preferred types of exons and introns
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Alternative splicing and evolution: diversification, exon definition and function
Keren, H., Lev-Maor, G., & Ast, G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2776 · Cited by 1,082
The origin of new genes: Glimpses from the young and old
Long, M., Betrán, E., Thornton, K., & Wang, W. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1204 · Cited by 933
Self-citationIntron—exon structures of eukaryotic model organisms
Long, M., & Deutsch, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3219 · Cited by 417
Self-citationNew Gene Evolution: Little Did We Know
Long, M., VanKuren, N. W., Chen, S., & Vibranovski, M. D. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133301 · Cited by 307
Self-citationIntron evolution as a population-genetic process
Lynch, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092595699 · Cited by 288
Metadata
- Authors
- Long, M., Rosenberg, C., & Gilbert, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-12-19
- Volume
- 92
- Issue
- 26
- Pages
- 12495-12499
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070709105
- Cited by
- 287
- References
- 30
- FWCI
- 22.71
- Type
- journal article
- Language
- en
- Open access
- green
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