The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine.
Open accessAbstract
We have determined the x-ray structure of a DNA fragment containing 7,8-dihydro-8-oxoguanine (G(O)). The structure of the duplex form of d(CCAGOCGCTGG) has been determined to 1.6-A resolution. The results demonstrate that GO forms Watson-Crick base pairs with the opposite C and that G(O) is in the anti conformation. Structural perturbations induced by C.G(O)anti base pairs are subtle. The structure allows us to identify probable elements by which the DNA repair protein MutM recognizes its substrates. Hydrogen bond donors/acceptors within the major groove are the most likely element. In that groove, the pattern of hydrogen-bond donors/acceptors of C.G(O)anti is unique. Additional structural analysis indicates that conversion of G to G(O) would not significantly influence the glycosidic torsion preference of the nucleoside. There is no steric interaction of the 8-oxygen of G(O) with the phospho-deoxyribose backbone.
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Citations
Cites
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
Mutagenesis by 8-oxoguanine: an enemy within
Grollman, A. P., & Moriya, M. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90089-z · Cited by 807
DNA replication fidelity with 8-oxodeoxyguanosine triphosphate
Pavlov, Y. I., Minnick, D. T., Izuta, S., & Kunkel, T. A. (1994) · Biochemistry · doi:10.1021/bi00181a029 · Cited by 132
Cited by
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence
Schuster, G. B. (2000) · Accounts of Chemical Research · doi:10.1021/ar980059z · Cited by 778
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
Wang, D., Kreutzer, D. A., & Essigmann, J. M. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00066-9 · Cited by 464
Self-citationMinimizing the damage: repair pathways keep mitochondrial DNA intact
Kazak, L., Reyes, A., & Holt, I. J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3439 · Cited by 388
Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair
Prakash, S., & Prakash, L. (2002) · Genes & Development · doi:10.1101/gad.1009802 · Cited by 344
Metadata
- Authors
- Lipscomb, L. A., Peek, M. E., Morningstar, M. L., Verghis, S. M., Miller, E. M., Rich, A., Essigmann, J. M., & Williams, L. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-01-31
- Volume
- 92
- Issue
- 3
- Pages
- 719-723
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047001643
- Cited by
- 224
- References
- 3
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine. https://app.cochat.ai/papers/10.1073/pnas.92.3.719
- The paper
- Lipscomb, L. A., Peek, M. E., Morningstar, M. L., Verghis, S. M., Miller, E. M., Rich, A., Essigmann, J. M., & Williams, L. D. (1995). X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.3.719
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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