Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence
Abstract
Damage to DNA is often caused by oxidative reactions. In one such process, an electron is lost from a base, forming its radical cation. Further reaction of the radical cation can lead to permanent change, which results in mutation. This Account is a report on oxidative damage to DNA caused by irradiation of anthraquinone derivatives, which are either randomly bound to the DNA or attached to it covalently at specific locations. Radical cations introduced in the DNA by the excited quinone cause damage both near to it and far away. We describe a mechanism for long-range charge transport in DNA that depends on its spontaneous structural distortion, which we call phonon-assisted polaron hopping. This mechanism, and its extension, provides a framework for understanding the reactions and charge-transport properties of DNA.
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A few photosensitizers, including anthraquinone, benzophenone, 1,4-dimethyl-2-naphthoquinone and riboflavin, can abstract one electron from adenine and pyrimidine bases in addition to guanine.
“A few photosensitizers including anthraquinone (137), benzophenone (138), 1,4-dimethyl-2-naphthoquinone (139) and riboflavin (140) are able to abstract one electron from adenine and pyrimidine bases in addition to guanine.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [137]
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- Authors
- Schuster, G. B.
- Affiliations
- Georgia Institute of Technology (US)
- Corresponding author
- Schuster, Gary B.
- ORCID
- Schuster, Gary B.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-02-29
- Volume
- 33
- Issue
- 4
- Pages
- 253-260
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W1969408680
- Cited by
- 778
- References
- 47
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 18 · 2018: 11 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 22 · 2013: 25 · 2012: 38
- FWCI
- 23.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Accounts of Chemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- long-range charge transfer, DNA, oxidative DNA damage, radical cations, anthraquinone derivatives, polaron hopping, phonon-assisted hopping, DNA structural distortion, distance dependence
- MeSH terms
- Anthraquinones, DNA, Kinetics, Nucleic Acid Conformation
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