Cited by 778DNA and Nucleic Acid ChemistryPhotochemistry and Electron Transfer StudiesAdvanced biosensing and bioanalysis techniques

Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence

Schuster, Gary B.·2000·Accounts of Chemical Research

Abstract

Damage to DNA is often caused by oxidative reactions. In one such process, an electron is lost from a base, forming its radical cation. Further reaction of the radical cation can lead to permanent change, which results in mutation. This Account is a report on oxidative damage to DNA caused by irradiation of anthraquinone derivatives, which are either randomly bound to the DNA or attached to it covalently at specific locations. Radical cations introduced in the DNA by the excited quinone cause damage both near to it and far away. We describe a mechanism for long-range charge transport in DNA that depends on its spontaneous structural distortion, which we call phonon-assisted polaron hopping. This mechanism, and its extension, provides a framework for understanding the reactions and charge-transport properties of DNA.

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Crossref · 10.1021/ar980059z

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  • A few photosensitizers, including anthraquinone, benzophenone, 1,4-dimethyl-2-naphthoquinone and riboflavin, can abstract one electron from adenine and pyrimidine bases in addition to guanine.

    “A few photosensitizers including anthraquinone (137), benzophenone (138), 1,4-dimethyl-2-naphthoquinone (139) and riboflavin (140) are able to abstract one electron from adenine and pyrimidine bases in addition to guanine.”

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Authors
Schuster, G. B.
Affiliations
Georgia Institute of Technology (US)
Corresponding author
Schuster, Gary B.
Venue
Accounts of Chemical Research
Published
2000-02-29
Volume
33
Issue
4
Pages
253-260
ISSN
  • 0001-4842 (ISSN-L)
  • 1520-4898
OpenAlex
W1969408680
Cited by
778
References
47
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 18 · 2018: 11 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 22 · 2013: 25 · 2012: 38
FWCI
23.75
Type
journal article
Language
en
Open access
closed
Locations
  • Accounts of Chemical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
long-range charge transfer, DNA, oxidative DNA damage, radical cations, anthraquinone derivatives, polaron hopping, phonon-assisted hopping, DNA structural distortion, distance dependence
MeSH terms
Anthraquinones, DNA, Kinetics, Nucleic Acid Conformation

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