The DOI matches its Crossref record.
Carbon monoxide: a role in carotid body chemoreception.
Open accessAbstract
Carbon monoxide (CO), produced endogenously by heme oxygenase, has been implicated as a neuronal messenger. Carotid bodies are sensory organs that regulate ventilation by responding to alterations of blood oxygen, CO2, and pH. Changes in blood gases are sensed by glomus cells in the carotid body that synapse on afferent terminals of the carotid sinus nerve that projects to respiratory-related neurons in the brainstem. Using immunocytochemistry, we demonstrate that heme oxygenase 2 is localized to glomus cells in the cat and rat carotid bodies. Physiological studies show that zinc protoporphyrin IX, a potent heme oxygenase inhibitor, markedly increases carotid body sensory activity, while copper protoporphyrin IX, which does not inhibit the enzyme, is inactive. Exogenous CO reverses the stimulatory effects of zinc protoporphyrin IX. These results suggest that glomus cells are capable of synthesizing CO and endogenous CO appears to be a physiologic regulator of carotid body sensory activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Pharmacological and Clinical Aspects of Heme Oxygenase
Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Lee, T.-S., & Chau, L.-Y. (2002) · Nature Medicine · doi:10.1038/nm0302-240 · Cited by 1,019
Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel
Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D. E., Riccardi, D., Peers, C., & Kemp, P. J. (2004) · Science · doi:10.1126/science.1105010 · Cited by 458
Zakhary, R., Gaine, S. P., Dinerman, J. L., Ruat, M., Flavahan, N. A., & Snyder, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.795 · Cited by 401
Self-citationH 2 S mediates O 2 sensing in the carotid body
Peng, Y.-J., Nanduri, J., Raghuraman, G., Souvannakitti, D., Gadalla, M. M., Kumar, G. K., Snyder, S. H., & Prabhakar, N. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005866107 · Cited by 361
Self-citation
Metadata
- Authors
- Prabhakar, N. R., Dinerman, J. L., Agani, F. H., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-14
- Volume
- 92
- Issue
- 6
- Pages
- 1994-1997
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106659867
- Cited by
- 193
- References
- 0
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Carbon monoxide: a role in carotid body chemoreception. https://app.cochat.ai/papers/10.1073/pnas.92.6.1994
- The paper
- Prabhakar, N. R., Dinerman, J. L., Agani, F. H., & Snyder, S. H. (1995). Carbon monoxide: a role in carotid body chemoreception. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.6.1994
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
