The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.
Open accessAbstract
Heme oxygenase 2 (HO-2), which synthesizes carbon monoxide (CO), has been localized by immunohistochemistry to endothelial cells and adventitial nerves of blood vessels. HO-2 is also localized to neurons in autonomic ganglia, including the petrosal, superior cervical, and nodose ganglia, as well as ganglia in the myenteric plexus of the intestine. Enzyme studies demonstrated that tin protoporphyrin-9 is a selective inhibitor of HO with approximately 10-fold selectivity for HO over endothelial nitric oxide synthase (NOS) and soluble guanylyl cyclase. Inhibition of HO activity by tin protoporphyrin 9 reverses the component of endothelial-derived relaxation of porcine distal pulmonary arteries not reversed by an inhibitor of NOS. Thus, CO, like NO, may have endothelial-derived relaxing activity. The similarity of NOS and HO-2 localizations and functions in blood vessels and the autonomic nervous system implies complementary and possibly coordinated physiologic roles for these two mediators.
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Cites
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Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
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Self-citationLocalization of nitric oxide synthase indicating a neural role for nitric oxide
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Self-citationNitric oxide, a novel neuronal messenger
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Self-citationNitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Bredt, D. S., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9030 · Cited by 1,840
Self-citationCarbon Monoxide: a Putative Neural Messenger
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Self-citationRole of nitric oxide synthesis in macrophage antimicrobial activity
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Cited by
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
H2S signalling through protein sulfhydration and beyond
Paul, B. D., & Snyder, S. H. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3391 · Cited by 853
Self-citationDoré, S., Takahashi, M., Ferris, C. D., Hester, L. D., Guastella, D., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2445 · Cited by 699
Self-citationHeme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Metadata
- Authors
- Zakhary, R., Gaine, S. P., Dinerman, J. L., Ruat, M., Flavahan, N. A., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-01-23
- Volume
- 93
- Issue
- 2
- Pages
- 795-798
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2131173683
- Cited by
- 401
- References
- 33
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Zakhary, R., Gaine, S. P., Dinerman, J. L., Ruat, M., Flavahan, N. A., & Snyder, S. H. (1996). Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.2.795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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