The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel
Abstract
Modulation of calcium-sensitive potassium (BK) channels by oxygen is important in several mammalian tissues, and in the carotid body it is crucial to respiratory control. However, the identity of the oxygen sensor remains unknown. We demonstrate that hemoxygenase-2 (HO-2) is part of the BK channel complex and enhances channel activity in normoxia. Knockdown of HO-2 expression reduced channel activity, and carbon monoxide, a product of HO-2 activity, rescued this loss of function. Inhibition of BK channels by hypoxia was dependent on HO-2 expression and was augmented by HO-2 stimulation. Furthermore, carotid body cells demonstrated HO-2–dependent hypoxic BK channel inhibition, which indicates that HO-2 is an oxygen sensor that controls channel activity during oxygen deprivation.
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Cites
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Self-citationHaem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels
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Cited by
Heme Enzyme Structure and Function
Poulos, T. L. (2014) · Chemical Reviews · doi:10.1021/cr400415k · Cited by 1,443
Genetic Evidence for High-Altitude Adaptation in Tibet
Simonson, T. S., Yang, Y., Huff, C. D., Yun, H., Qin, G., Witherspoon, D. J., Bai, Z., Lorenzo, F. R., Xing, J., Jorde, L. B., et al. (2010) · Science · doi:10.1126/science.1189406 · Cited by 1,227
Pharmacological and Clinical Aspects of Heme Oxygenase
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Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
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CO AS A CELLULAR SIGNALING MOLECULE
Kim, H. P., Ryter, S. W., & Choi, A. M. K. (2006) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141053 · Cited by 426
Metadata
- Authors
- Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D. E., Riccardi, D., Peers, C., & Kemp, P. J.
- Venue
- Science
- Published
- 2004-12-17
- Volume
- 306
- Issue
- 5704
- Pages
- 2093-2097
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964320031
- Cited by
- 458
- References
- 15
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D. E., Riccardi, D., Peers, C., & Kemp, P. J. (2004). Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel. Science. https://doi.org/10.1126/science.1105010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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