The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.
Open accessAbstract
Agonists of the dopamine D1/D5 receptors that are positively coupled to adenylyl cyclase specifically induce a slowly developing long-lasting potentiation of the field excitatory postsynaptic potential in the CA1 region of the hippocampus that lasts for > 6 hr. This potentiation is blocked by the specific D1/D5 receptor antagonist SCH 23390 and is occluded by the potentiation induced by cAMP agonists. An agonist of the D2 receptor, which is negatively coupled to adenylyl cyclase through G alpha i, did not induce potentiation. Although this slow D1/D5 agonist-induced potentiation is partially independent of N-methyl-D-aspartate receptors, it seems to share some steps with and is occluded by the late phase of long-term potentiation (LTP) produced by three repeated trains of nerve stimuli applied to the Schaffer collateral pathway. Similarly, the D1/D5 antagonist SCH 23390 attenuates the late phase of the LTP induced by repeated trains, and the D1/D5 agonist-induced potentiation is blocked by the protein synthesis inhibitor anisomycin. These results suggest that the D1/D5 receptor may be involved in the late, protein synthesis-dependent component of LTP in the hippocampal CA1 region, either as an ancillary component or as a mediator directly contributing to the late phase.
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Cites
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Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
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Self-citationRequirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
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Self-citationMolecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.
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Cited by
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The molecular biology of memory storage: a dialogue between genes and synapses
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Self-citationNEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
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Metadata
- Authors
- Huang, Y. Y., & Kandel, E. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-28
- Volume
- 92
- Issue
- 7
- Pages
- 2446-2450
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020969390
- Cited by
- 543
- References
- 28
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. https://app.cochat.ai/papers/10.1073/pnas.92.7.2446
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- Huang, Y. Y., & Kandel, E. R. (1995). D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.7.2446
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
