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Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein.
Open accessAbstract
The SSN6-TUP1 protein complex represses transcription of diversely regulated genes in the yeast Saccharomyces cerevisiae. Here we present evidence that MIG1, a zinc-finger protein in the EGR1/Zif268 family, recruits SSN6-TUP1 to glucose-repressed promoters. DNA-bound LexA-MIG1 represses transcription of a target gene in glucose-grown cells, and repression requires SSN6 and TUP1. We also show that MIG1 and SSN6 fusion proteins interact in the two-hybrid system. Unexpectedly, we found that LexA-MIG1 activates transcription strongly in an ssn6 mutant and weakly in a tup1 mutant. Finally, LexA-MIG1 does not repress transcription in glucose-deprived cells, and MIG1 is differentially phosphorylated in response to glucose availability. We suggest a role for phosphorylation in regulating repression.
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Citations
Cited by
Hedbacker, K. (2008) · Frontiers in Bioscience · doi:10.2741/2854 · Cited by 554
Metabolic Engineering of Saccharomyces cerevisiae
Ostergaard, S., Olsson, L., & Nielsen, J. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.1.34-50.2000 · Cited by 462
NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans
Murad, A. M. A., Leng, P., Straffon, M., Wishart, J., Macaskill, S., MacCallum, D., Schnell, N., Talibi, D., Marechal, D., Tekaia, F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4742 · Cited by 452
NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction
Braun, B. R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4753 · Cited by 344
Murad, A. M. A., D'Enfert, C., Gaillardin, C., Tournu, H., Tekaia, F., Talibi, D., Marechal, D., Marchais, V., Cottin, J., & Brown, A. J. P. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02713.x · Cited by 208
Metadata
- Authors
- Treitel, M. A., & Carlson, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-04-11
- Volume
- 92
- Issue
- 8
- Pages
- 3132-3136
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2091567823
- Cited by
- 394
- References
- 0
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. https://app.cochat.ai/papers/10.1073/pnas.92.8.3132
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- Treitel, M. A., & Carlson, M. (1995). Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.8.3132
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
