SNF1/AMPK pathways in yeast

Hedbacker, Kristina

doi:10.2741/2854

Cited by 554Fungal and yeast genetics researchMetabolism, Diabetes, and CancerBacterial Genetics and Biotechnology

SNF1/AMPK pathways in yeast

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Hedbacker, Kristina·2008·Frontiers in Bioscience

DOI 10.2741/2854PMC PMC2685184

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Abstract

The SNF1/AMPK family of protein kinases is highly conserved in eukaryotes and is required for energy homeostasis in mammals, plants, and fungi. SNF1 protein kinase was initially identified by genetic analysis in the budding yeast Saccharomyces cerevisiae. SNF1 is required primarily for the adaptation of yeast cells to glucose limitation and for growth on carbon sources that are less preferred than glucose, but is also involved in responses to other environmental stresses. SNF1 regulates transcription of a large set of genes, modifies the activity of metabolic enzymes, and controls various nutrient-responsive cellular developmental processes. Like AMPK, SNF1 protein kinase is heterotrimeric. It is phosphorylated and activated by the upstream kinases Sak1, Tos3, and Elm1 and is inactivated by the Reg1-Glc7 protein phosphatase 1. Further regulation of SNF1 is achieved through autoinhibition and through control of its subcellular localization. Here we review the current understanding of SNF1 protein kinase pathways in Saccharomyces cerevisiae and other yeasts.

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Snf1 and Hog1 MAPK regulate global changes in gene expressions for utilizing alternate carbon sources in Crabtree-positive yeasts upon phosphorylation.
“Also, the Snf1 and the Hog1 MAPK regulate global changes in gene expressions for utilizing alternate carbon sources in Crabtree-positive yeasts upon phosphorylation (27, 28)”
From Divergent mitochondrial responses and metabolic signal pathways secure the azole resistance in Crabtree-positive and negative <i>Candida</i> species (2024) · cites this paper as [27]
Section 6.1 (page not provided) says SNF1 regulates a large set of genes, including genes for alternative-carbon-source metabolism. The regulation-of-catalytic-activity section says SNF1 is activated by phosphorylation during glucose limitation. Our copy does not support the added role for Hog1 MAPK or specify that this finding applies to Crabtree-positive yeasts as a group. (LLM, conf=0.90)
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Hawley, S. A., J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd, T. P. Makela, D. R. Alessi & D. G. Hardie: Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol, 2, 28 (2003)

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Authors: Hedbacker, K.
Affiliations: Columbia University (US)
Corresponding author: Hedbacker, Kristina
ORCID: Hedbacker, Kristina
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2008
Volume: 13
Issue: 13
Pages: 2408
ISSN: 1093-4715 (ISSN-L)
1093-9946
DOI: 10.2741/2854
PMC: PMC2685184
OpenAlex: W2047373064
Cited by: 554
References: 125
Citations by year: 2026: 18 · 2025: 25 · 2024: 19 · 2023: 39 · 2022: 24 · 2021: 52 · 2020: 34 · 2019: 29 · 2018: 35 · 2017: 25 · 2016: 21 · 2015: 33 · 2014: 40 · 2013: 37 · 2012: 26
FWCI: 1.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Frontiers in bioscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R37GM034095, R01GM034095, GM-34095)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Snf1 kinase, AMPK, energy homeostasis, Saccharomyces cerevisiae, glucose limitation, carbon source preference, environmental stress response, transcriptional regulation, protein phosphorylation, protein dephosphorylation, protein phosphatase 1, autoinhibition, subcellular localization, yeast
MeSH terms: Carbon, Carrier Proteins, Catalysis, Environment, Glucose, Models, Biological, Multienzyme Complexes, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Enzymologic, Genome, Fungal, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Catalytic Domain, Saccharomyces cerevisiae Proteins, AMP-Activated Protein Kinases

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