The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.
Open accessAbstract
We have molecularly cloned a calcium sensing receptor (CaSR) from a rat striatal cDNA library. Rat CaSR displays 92% overall homology to its bovine counterpart with seven putative transmembrane domains characteristic of the superfamily of guanine nucleotide-binding proteins and significant homology with the metabotropic glutamate receptors. Northern blot analysis reveals two transcripts in thyroid, kidney, lung, ileum, and pituitary. In brain highest regional expression of the RNA occurs in the hypothalamus and the corpus striatum. Immunohistochemistry reveals discrete punctate localizations throughout the brain that appear to be associated with nerve terminals. No staining is evident in cell bodies of neurons or glia. Cerebral arteries display an intense network of CaSR immunoreactive fibers associated with vessel innervation. CaSR on nerve terminal membranes may regulate neurotransmitter disposition in response to Ca2+ levels in the synaptic space.
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Cites
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Cited by
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases
Hannan, F. M., Kallay, E., Chang, W., Brandi, M. L., & Thakker, R. V. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0115-0 · Cited by 394
Sweet taste signaling functions as a hypothalamic glucose sensor
Ren, X. (2009) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.012.2009 · Cited by 267
Gonzelez-Suerez, I., ÁLvarez-Hernendez, D., Carrillo-Lepez, N., Naves-Deaz, M., Luis Fernendez-Marten, J., & Cannata-Andea, J. B. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00724.x · Cited by 16
Metadata
- Authors
- Ruat, M., Molliver, M. E., Snowman, A. M., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-04-11
- Volume
- 92
- Issue
- 8
- Pages
- 3161-3165
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065390805
- Cited by
- 375
- References
- 24
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Ruat, M., Molliver, M. E., Snowman, A. M., & Snyder, S. H. (1995). Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.8.3161
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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