Cited by 545Protein Structure and DynamicsRNA and protein synthesis mechanismsProtein purification and stability

Nucleation mechanisms in protein folding

Fersht, Alan R·1997·Current Opinion in Structural Biology

Abstract

Experiment and theory are converging on the importance of nucleation mechanisms in protein folding. These mechanisms do not use classic nuclei, which are well formed elements of structure present in ground states, but they use diffuse, extended regions, which are observed in transition states.

Integrity signals

Registry

Crossref · 10.1016/s0959-440x(97)80002-4

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • AlphaFold does not resolve the protein folding problem and does not identify folding pathways.

    “AlphaFold does not resolve the decades-long protein folding challenge, nor does it identify the folding pathways.”

    From AlphaFold, Artificial Intelligence (AI), and Allostery (2022) · cites this paper as [54]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Fersht, A. R.
Affiliations
University of Cambridge (GB)
Corresponding author
Fersht, Alan R
Venue
Current Opinion in Structural Biology
Publisher
Elsevier BV
Published
1997-02
Volume
7
Issue
1
Pages
3-9
ISSN
0959-440X (ISSN-L)
OpenAlex
W2079884830
Cited by
545
References
72
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 19
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Structural Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords
protein folding, nucleation mechanism, folding transition state, folding kinetics, folding free energy landscape
MeSH terms
Kinetics, Protein Conformation, Protein Folding

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review