The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.
Open accessAbstract
Baculovirus inhibitors of apoptosis (IAPs) act in insect cells to prevent cell death. Here we describe three mammalian homologs of IAP, MIHA, MIHB, and MIHC, and a Drosophila IAP homolog, DIHA. Each protein bears three baculovirus IAP repeats and an N-terminal ring finger motif. Apoptosis mediated by interleukin 1beta converting enzyme (ICE), which can be inhibited by Orgyia pseudotsugata nuclear polyhedrosis virus IAP (OpIAP) and cowpox virus crmA, was also inhibited by MIHA and MIHB. As MIHB and MIHC were able to bind to the tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 in yeast two-hybrid assays, these results suggest that IAP proteins that inhibit apoptosis may do so by regulating signals required for activation of ICE-like proteases.
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Cites
Genetic control of programmed cell death in the nematode C. elegans
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Cited by
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Self-citationIAP proteins: blocking the road to death's door
Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm830 · Cited by 1,756
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IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
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The inhibitors of apoptosis (IAPs) as cancer targets
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The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases
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IAPs limit activation of RIP kinases by TNF receptor 1 during development
Moulin, M., Anderton, H., Voss, A. K., Thomas, T., Wong, W. W., Bankovacki, A., Feltham, R., Chau, D., Cook, W. D., Silke, J., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.18 · Cited by 193
Self-citationOkuhira, K., Ohoka, N., Sai, K., Nishimaki-Mogami, T., Itoh, Y., Ishikawa, M., Hashimoto, Y., & Naito, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.019 · Cited by 118
XIAP regulates intracellular ROS by enhancing antioxidant gene expression
Resch, U., Schichl, Y. M., Sattler, S., & de Martin, R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.142 · Cited by 41
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Metadata
- Authors
- Uren, A. G., Pakusch, M., Hawkins, C. J., Puls, K. L., & Vaux, D. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-05-14
- Volume
- 93
- Issue
- 10
- Pages
- 4974-4978
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2000623989
- Cited by
- 511
- References
- 2
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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