Cytoprotective effects of fucoidan, an algae-derived polysaccharide on 5-fluorouracil-treated dendritic cells
Abstract
Although chemotherapeutic anticancer agents are effective, they also attack normal immune cells due to a lack of selectivity. 5-Fluorouracil (5-FU) is a representative anticancer agent that induces immunosuppression in cancer patients as a side effect. Fucoidan is an algae-derived sulfated polysaccharide that has recently been recognized as a hematopoietic mobilizer and immunomodulator. In this study, we investigated the cytoprotective effect of fucoidan on dendritic cells (DCs) against 5-FU-induced cellular damage. Several kinds of assays including flow cytometric analysis demonstrated the cytoprotective efficacy of fucoidan. In addition, fucoidan increased the expression of immune-related surface markers on and the alloproliferative capacity of DCs exposed to 5-FU. For investigating action mechanism, the expression levels of apoptosis-related molecules were measured. Taken together, the results of this study suggest that fucoidan, a marine-derived polysaccharide, has cytoprotective effects on DCs, the most potent antigen-presenting cell type, against 5-FU-induced cellular damage. These results provide valuable information to use fucoidan as an immunostimulatory agent for the chemotherapy of cancer patients.
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Fucoidan may be useful for recovery of 5-FU-treated antigen-presenting dendritic cells.
“It is important that fucoidan may be useful for the recovery of 5-fluorouracil (5-FU)-treated antigen-presenting dendritic cells, because this clinical anticancer agent induces immunosuppression in cancer patients as a side effect [60].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [60]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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- Authors
- Jeong, B.-E., Ko, E.-J., & Joo, H.-G.
- Affiliations
- Jeju National University (KR)
- Corresponding author
- Joo, Hong-Gu
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 50
- Issue
- 5
- Pages
- 1480-1484
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2041671152
- Cited by
- 39
- References
- 29
- Citations by year
- 2025: 3 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- fucoidan, 5-fluorouracil, dendritic cells, cytoprotection, sulfated polysaccharides, chemotherapy-induced immunosuppression, apoptosis, antigen presentation, immunostimulants
- MeSH terms
- Animals, Antimetabolites, Antineoplastic, Dendritic Cells, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Fluorouracil, Lymphocyte Culture Test, Mixed, Mice, Inbred BALB C, Mice, Inbred C57BL, Polysaccharides, Tumor Necrosis Factor-alpha, Up-Regulation, Apoptosis, Interleukin-12, Mice, Microalgae
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