The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.
Open accessAbstract
Site-specific recombinases are being developed as tools for "in vivo" genetic engineering because they can catalyze precise excisions, integrations, inversions, or translocations of DNA between their distinct recognition target sites. Here it is demonstrated that Flp recombinase can effectively mediate site-specific excisional recombination in mouse embryonic stem cells, in differentiating embryonal carcinoma cells, and in transgenic mice. Broad Flp expression is compatible with normal development, suggesting that Flp can be used to catalyze recombination in most cell types. These properties indicate that Flp can be exploited to make prescribed alterations in the mouse genome.
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Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
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Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470
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Metadata
- Authors
- Dymecki, S. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-06-11
- Volume
- 93
- Issue
- 12
- Pages
- 6191-6196
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971075145
- Cited by
- 363
- References
- 1
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Dymecki, S. M. (1996). Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.12.6191
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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