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P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
Open accessAbstract
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.
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Cited by
Szeto, D. P., Rodriguez-Esteban, C., Ryan, A. K., O'Connell, S. M., Liu, F., Kioussi, C., Gleiberman, A. S., Izpisua-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.4.484 · Cited by 426
Self-citationHindlimb patterning and mandible development require the Ptx1 gene
Lanctôt, C., Moreau, A., Chamberland, M., Tremblay, M. L., & Drouin, J. (1999) · Development · doi:10.1242/dev.126.9.1805 · Cited by 311
Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity
Logan, M., & Tabin, C. J. (1999) · Science · doi:10.1126/science.283.5408.1736 · Cited by 304
Tremblay, J. J., & Drouin, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2567 · Cited by 272
Fan, S., Kelly, D. E., Beltrame, M. H., Hansen, M. E. B., Mallick, S., Ranciaro, A., Hirbo, J., Thompson, S., Beggs, W., Nyambo, T., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1679-2 · Cited by 194
Metadata
- Authors
- Szeto, D. P., Ryan, A. K., O'Connell, S. M., & Rosenfeld, M. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-07-23
- Volume
- 93
- Issue
- 15
- Pages
- 7706-7710
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967424239
- Cited by
- 266
- References
- 0
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. https://app.cochat.ai/papers/10.1073/pnas.93.15.7706
- The paper
- Szeto, D. P., Ryan, A. K., O'Connell, S. M., & Rosenfeld, M. G. (1996). P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.15.7706
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
