Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity

A series of normal stages in the development of the chick embryo

Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254 · see citing works

Sonic hedgehog mediates the polarizing activity of the ZPA

Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285 · see citing works

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

Crossley, P. H., Minowada, G., MacArthur, C. A., & Martin, G. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80999-x · Cited by 583 · see citing works

Fibroblast growth factors induce additional limb development from the flank of chick embryos

Cohn, M. J., Izpisúa‐Belmonte, J. C., Abud, H. E., Heath, J. K., & Tickle, C. A. (1995) · Cell · doi:10.1016/0092-8674(95)90352-6 · Cited by 573 · see citing works

Analysis of Hox gene expression in the chick limb bud

Nelson, C. E., Morgan, B. A., Burke, A. C., Laufer, E., DiMambro, E., Murtaugh, L. C., Gonzales, E., Tessarollo, L., Parada, L. F., & Tabin, C. J. (1996) · Development · doi:10.1242/dev.122.5.1449 · Cited by 481 · see citing works

The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals

Logan, M. P. O., Pagán-Westphal, S. M., Smith, D. M., Paganessi, L. A., & Tabin, C. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81474-9 · Cited by 455 · see citing works

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.Preprint

Lamonerie, T., Tremblay, J., Lanctôt, C., Therrien, M., Gauthier, Y., & Drouin, J. (1996) · Genes & Development · doi:10.1101/gad.10.10.1284 · Cited by 421 · see citing works

Muscle and tendon morphogenesis in the avian hind limb

Kardon, G. (1998) · Development · doi:10.1242/dev.125.20.4019 · Cited by 408 · see citing works

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

Vogel, A., Rodriguez, C., & Izpisúa‐Belmonte, J. C. (1996) · Trends in Genetics · doi:10.1016/s0168-9525(96)80013-8 · Cited by 333 · see citing works

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

Vogel, A., Rodriguez, C., & Izpisúa‐Belmonte, J. C. (1996) · Development · doi:10.1242/dev.122.6.1737 · Cited by 322 · see citing works

The Expression and Function of Notch Pathway Genes in the Developing Rat Eye

Bao, Z., & Cepko, C. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01425.1997 · Cited by 293 · see citing works

Evidence of a role for T-☐ genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity

Gibson-Brown, J., Agulnik, S., Chapman, D. L., Alexiou, M., Garvey, N., Lee, S., & Papaioannou, V. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00514-x · Cited by 288 · see citing works

P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.

Szeto, D. P., Ryan, A. K., O’Connell, S. M., & Rosenfeld, M. G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7706 · Cited by 265 · see citing works

The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm

Lanctôt, C., Lamolet, B., & Drouin, J. (1997) · Development · doi:10.1242/dev.124.14.2807 · Cited by 220 · see citing works

Targeted Gene Misexpression in Chick Limb Buds Using Avian Replication-Competent Retroviruses

Logan, M. P. O., & Tabin, C. (1998) · Methods · doi:10.1006/meth.1998.0595 · Cited by 140 · see citing works

An Additional Limb Can Be Induced from the Flank of the Chick Embryo by FGF4

Ohuchi, H., Nakagawa, T., Yamauchi, M., Ohata, T., Yoshioka, H., Kuwana, T., Mima, T., Mikawa, T., Nohno, T., & Noji, S. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1572 · Cited by 106 · see citing works

A novel family of T-box genes in urodele amphibian limb development and regeneration: candidate genes involved in vertebrate forelimb/hindlimb patterning

Simon, H., Kittappa, R., Khan, P. A., Tsilfidis, C., Liversage, R. A., & Oppenheimer, S. (1997) · Development · doi:10.1242/dev.124.7.1355 · Cited by 85 · see citing works

The development of the muscles and tendons in the lower leg and foot of chick embryos

Wortham, R. A. (1948) · Journal of Morphology · doi:10.1002/jmor.1050830106 · Cited by 55 · see citing works

The pattern of muscle development in the chick leg.

Pautou, M.-P., Hedayat, I., & Kieny, M. (1982) · PubMed · Cited by 28 · see citing works

Development of wing‐bud‐derived muscles in normal and wingless chick embryos: A computer‐assisted three‐dimensional reconstruction study of muscle pattern formation in the absence of skeletal elements

Lanser, M. E., & Fallon, J. F. (1987) · The Anatomical Record · doi:10.1002/ar.1092170110 · Cited by 27 · see citing works

Backfoot, a Novel Homeobox Gene, Maps to Human Chromosome 5 (BFT) and Mouse Chromosome 13 (Bft)

Shang, J., Li, X., Ring, H. Z., Clayton, D. A., & Francke, U. (1997) · Genomics · doi:10.1006/geno.1996.4558 · Cited by 20 · see citing works

Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks

Shapiro, M. D., Marks, M. E., Peichel, C. L., Blackman, B. K., Nereng, K. S., Jónsson, B., Schluter, D., & Kingsley, D. M. (2004) · Nature · doi:10.1038/nature02415 · Cited by 843 · see citing works

Bone Development

Olsen, B. R., Reginato, A. M., & Wang, W. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.191 · Cited by 828 · see citing works

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

Lin, C. R., Kioussi, C., O’Connell, S. M., Briata, P., Szeto, D. P., Liu, F. C., Izpisúa‐Belmonte, J. C., & Rosenfeld, M. G. (1999) · Nature · doi:10.1038/45803 · Cited by 612 · see citing works

Mechanisms of retinoic acid signalling and its roles in organ and limb development

Cunningham, T. J., & Duester, G. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3932 · Cited by 602 · see citing works

A Pituitary Cell-Restricted T Box Factor, Tpit, Activates POMC Transcription in Cooperation with Pitx Homeoproteins

Lamolet, B., Pulichino, A.-M., Lamonerie, T., Gauthier, Y., Brue, T. C., Enjalbert, A., & Drouin, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00282-3 · Cited by 541 · see citing works

Evolution of Gene Regulatory Networks Controlling Body Plan Development

Peter, I. S., & Davidson, E. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.017 · Cited by 417 · see citing works

Patterning Mechanisms Controlling Vertebrate Limb Development

Capdevila, J., & Belmonte, J. C. I. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.87 · Cited by 399 · see citing works

Canalization, developmental stability, and morphological integration in primate limbs

Hallgrímsson, B., Willmore, K. E., & Hall, B. K. (2002) · American Journal of Physical Anthropology · doi:10.1002/ajpa.10182 · Cited by 391 · see citing works

DUX4 , a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1

Dixit, M., Ansseau, E., Tassin, A., Winokur, S. T., Shi, R., Qian, H., Sauvage, S., Mattéotti, C., Acker, A.-M. V., Léo, O., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708659104 · Cited by 387 · see citing works

SERIAL HOMOLOGY AND THE EVOLUTION OF MAMMALIAN LIMB COVARIATION STRUCTURE

Young, N. M., & Hallgrímsson, B. (2005) · Evolution · doi:10.1111/j.0014-3820.2005.tb00980.x · Cited by 324 · see citing works

The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity

Rodrı́guez-Esteban, C., Tsukui, T., Yonei‐Tamura, S., Magallon, J., Tamura, K., & Belmonte, J. C. I. (1999) · Nature · doi:10.1038/19769 · Cited by 307 · see citing works

Theheartstringsmutation in zebrafish causes heart/fin Tbx5 deficiency syndrome

Garrity, D. M., Childs, S. J., & Fishman, M. C. (2002) · Development · doi:10.1242/dev.129.19.4635 · Cited by 295 · see citing works

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

Stennard, F. A., Costa, M. W., Elliott, D. A., Rankin, S. A., Haast, S. J. P., Lai, D., McDonald, L., Niederreither, K., Dollé, P., Bruneau, B. G., et al. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00385-3 · Cited by 289 · see citing works

Tbx5is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

Agarwal, P., Wylie, J. N., Galcerán, J., Arkhitko, O., Li, C., Deng, C., Grosschedl, R., & Bruneau, B. G. (2003) · Development · doi:10.1242/dev.00191 · Cited by 277 · see citing works

Isl1Cre reveals a common Bmp pathway in heart and limb development

Yang, L., Cai, C.-L., Lin, L., Qyang, Y., Chung, C., Monteiro, R. M., Mummery, C. L., Fishman, G. I., Cogen, A., & Evans, S. (2006) · Development · doi:10.1242/dev.02322 · Cited by 267 · see citing works

Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois

Naiche, L. A., & Papaioannou, V. E. (2003) · Development · doi:10.1242/dev.00504 · Cited by 251 · see citing works

Tbx5 is required for forelimb bud formation and continued outgrowth

Rallis, C., Bruneau, B. G., Buono, J. D., Seidman, C. E., Seidman, J. G., Nissim, S., Tabin, C. J., & Logan, M. P. O. (2003) · Development · doi:10.1242/dev.00473 · Cited by 241 · see citing works

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation

Takeuchi, S., Takeda, K., Oishi, I., Nomi, M., Ikeya, M., Itoh, K., Tamura, S., Ueda, T., Hatta, T., Otani, H., et al. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00300.x · Cited by 224 · see citing works

Parallel genetic origins of pelvic reduction in vertebrates

Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604706103 · Cited by 216 · see citing works

The limb identity geneTbx5promotes limb initiation by interacting withWnt2bandFgf10

Ng, J. K., Kawakami, Y., Büscher, D., Raya, Á., Itoh, T., Koth, C. M., Esteban, C. R., Rodríguez‐León, J., Garrity, D. M., Fishman, M. C., et al. (2002) · Development · doi:10.1242/dev.129.22.5161 · Cited by 209 · see citing works

Signaling and Transcriptional Mechanisms in Pituitary Development

Dasen, J. S., & Rosenfeld, M. G. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.327 · Cited by 208 · see citing works

Antagonistic Signals between BMP4 and FGF8 Define the Expression of Pitx1 and Pitx2 in Mouse Tooth-Forming Anlage

Amand, T. R. S., Zhang, Y., Semina, E. V., Zhao, X., Hu, Y., Nguyen, L., Murray, J. C., & Chen, Y. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9547 · Cited by 208 · see citing works

T-box genes in human disorders

Packham, E. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg077 · Cited by 202 · see citing works

T-box genes in development: From hydra to humans

Papaioannou, V. E. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)07002-4 · Cited by 192 · see citing works

Limb development: a paradigm of gene regulation

Petit, F., Sears, K. E., & Ahituv, N. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.167 · Cited by 188 · see citing works

Mutations in the Human TBX4 Gene Cause Small Patella Syndrome

Bongers, E. M. H. F., Duijf, P. H. G., van Beersum, S. E. C., Schoots, J., van Kampen, A., Burckhardt, A., Hamel, B. C. J., Losan, F., Hoefsloot, L. H., Yntema, H. G., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/421331 · Cited by 185 · see citing works

Pitx1andPitx2are required for development of hindlimb buds

Marcil, A., Dumontier, É., Chamberland, M., Camper, S. A., & Drouin, J. (2002) · Development · doi:10.1242/dev.00192 · Cited by 177 · see citing works

The Spectrum of Mutations in TBX3: Genotype/Phenotype Relationship in Ulnar-Mammary Syndrome

Bamshad, M., Le, T., Watkins, W. S., Dixon, M. E., Kramer, B. E., Roeder, A. D., Carey, J. C., Root, S., Schinzel, A., Van Maldergem, L., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302417 · Cited by 175 · see citing works

Retinoic Acid Promotes Limb Induction through Effects on Body Axis Extension but is Unnecessary for Limb Patterning

Zhao, X.-L., Sirbu, I. O., Mic, F., Molotkova, N., Molotkov, A., Kumar, S., & Duester, G. (2009) · Current Biology · doi:10.1016/j.cub.2009.04.059 · Cited by 178 · see citing works

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics · doi:10.1038/ng1707 · Cited by 170 · see citing works

Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb

DeLaurier, A., Schweitzer, R., & Logan, M. P. O. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.055 · Cited by 159 · see citing works

Tbx5 and Tbx4 Are Not Sufficient to Determine Limb-Specific Morphologies but Have Common Roles in Initiating Limb Outgrowth

Minguillón, C., Buono, J. D., & Logan, M. P. O. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.11.013 · Cited by 154 · see citing works

Specific Protein-Protein Interaction between Basic Helix-Loop-Helix Transcription Factors and Homeoproteins of the Pitx Family

Poulin, G. B., Lebel, M., Chamberland, M., Paradis, F., & Drouin, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4826-4837.2000 · Cited by 152 · see citing works

Asymmetric Lower-Limb Malformations in Individuals with Homeobox PITX1 Gene Mutation

Gurnett, C. A., Alaee, F., Kruse, L. M., Desruisseau, D. M., Hecht, J. T., Wise, C. A., Bowcock, A. M., & Dobbs, M. B. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.10.004 · Cited by 150 · see citing works

Determinants of T box protein specificity

Conlon, F. L., Fairclough, L., Price, B. M. J., Casey, E. S., & Smith, J. C. (2001) · Development · doi:10.1242/dev.128.19.3749 · Cited by 148 · see citing works

Developmental Biology and Human Evolution

Lovejoy, C. O., McCollum, M. A., Reno, P. L., & Rosenman, B. A. (2003) · Annual Review of Anthropology · doi:10.1146/annurev.anthro.32.061002.093223 · Cited by 148 · see citing works

How the embryo makes a limb: determination, polarity and identity

Tickle, C. A. (2015) · Journal of Anatomy · doi:10.1111/joa.12361 · Cited by 146 · see citing works

DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: The role of HOX genes and physical activity

Turner, D. C., Gorski, P. P., Maasar, M. F., Seaborne, R. A., Baumert, P., Brown, A. D., Kitchen, M. O., Erskine, R. M., Dos-Remedios, I., Voisin, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72730-z · Cited by 139 · see citing works

Regulatory evolution and the origin of the bilaterians

Peterson, K. J., & Davidson, E. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4430 · Cited by 139 · see citing works

Genetic and developmental bases of serial homology in vertebrate limb evolution

Ruvinsky, I., & Gibson‐Brown, J. J. (2000) · Development · doi:10.1242/dev.127.24.5233 · Cited by 134 · see citing works

CpG island methylation profiling in human salivary gland adenoid cystic carcinoma

Bell, A., Bell, D., Weber, R. S., & El‐Naggar, A. K. (2011) · Cancer · doi:10.1002/cncr.25818 · Cited by 126 · see citing works

Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme

Holleville, N., Matéos, S., Bontoux, M., Bollérot, K., & Monsoro-Burq, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.003 · Cited by 122 · see citing works

THE COEVOLUTION OF HUMAN HANDS AND FEET

Rolian, C., Lieberman, D. E., & Hallgrímsson, B. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00944.x · Cited by 121 · see citing works

Molecular genetic cascades for external genitalia formation: An emerging organogenesis program

Yamada, G., Suzuki, K., Haraguchi, R., Miyagawa, S., Satoh, Y., Kamimura, M., Nakagata, N., Kataoka, H., Kuroiwa, A., & Chen, Y. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20807 · Cited by 120 · see citing works

Homeotic Arm-to-Leg Transformation Associated with Genomic Rearrangements at the PITX1 Locus

Spielmann, M., Brancati, F., Krawitz, P. M., Robinson, P. N., Ibrahim, D. M., Franke, M., Hecht, J., Lohan, S. B., Dathe, K., Nardone, A. M., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.08.014 · Cited by 118 · see citing works

Genetics of clubfoot

Dobbs, M. B., & Gurnett, C. A. (2011) · Journal of Pediatric Orthopaedics B · doi:10.1097/bpb.0b013e328349927c · Cited by 114 · see citing works

Developmental origins of precocial forelimbs in marsupial neonates

Keyte, A. L., & Smith, K. K. (2010) · Development · doi:10.1242/dev.049445 · Cited by 110 · see citing works

Regulation of limb bud initiation and limb‐type morphology

Duboc, V., & Logan, M. P. O. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22582 · Cited by 105 · see citing works

Vertebrate aristaless-related genes

Meijlink, F. C. P. W., Beverdam, A., Brouwer, A., Oosterveen, T., & ten Berge, D. (1999) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10668975 · Cited by 105 · see citing works

Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper

Yin, W. H., Wang, Z., Li, Q., Lian, J.-M., Zhou, Y., Lu, B., Jin, L.-J., Qiu, P., Zhang, P., Zhu, W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13107 · Cited by 103 · see citing works

Transcriptional Properties of Ptx1 and Ptx2 Isoforms

Tremblay, J., Goodyer, C. G., & Drouin, J. (2000) · Neuroendocrinology · doi:10.1159/000054547 · Cited by 102 · see citing works

THE COEVOLUTION OF HUMAN HANDS AND FEET

Rolian, C., Lieberman, D. E., & Hallgrímsson, B. (2010) · Evolution · doi:10.1111/j.1558-5646.2010.00944.x · Cited by 101 · see citing works

Vertebrate limb development — the early stages in chick and mouse

Tickle, C. A., & Münsterberg, A. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00220-3 · Cited by 101 · see citing works

Current molecular understanding of Axenfeld–Rieger syndrome

Hjalt, T. Å. H., & Semina, E. V. (2005) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399405010082 · Cited by 100 · see citing works

The Genetic Architecture of Skeletal Convergence and Sex Determination in Ninespine Sticklebacks

Shapiro, M. D., Summers, B. R., Balabhadra, S., Aldenhoven, J., Miller, A. L., Cunningham, C. B., Bell, M. A., & Kingsley, D. M. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.029 · Cited by 96 · see citing works

MORPHOLOGICAL INTEGRATION IN MAMMALIAN LIMB PROPORTIONS: DISSOCIATION BETWEEN FUNCTION AND DEVELOPMENT

Schmidt, M., & Fischer, M. S. (2008) · Evolution · doi:10.1111/j.1558-5646.2008.00583.x · Cited by 96 · see citing works

Analysis of a key regulatory region upstream of theMyf5gene reveals multiple phases of myogenesis, orchestrated at each site by a combination of elements dispersed throughout the locus

Hadchouel, J., Carvajal, J. J., Daubas, P., Bajard, L., Chang, T. H., Rocancourt, D., Cox, D., Summerbell, D., Tajbakhsh, S., Rigby, P. W. J., et al. (2003) · Development · doi:10.1242/dev.00552 · Cited by 95 · see citing works

About face: Signals and genes controlling jaw patterning and identity in vertebrates

Richman, J. M., & Lee, S. (2003) · BioEssays · doi:10.1002/bies.10288 · Cited by 94 · see citing works

Dual hindlimb control elements in theTbx4gene and region-specific control of bone size in vertebrate limbs

Menke, D. B., Guenther, C. A., & Kingsley, D. M. (2008) · Development · doi:10.1242/dev.017384 · Cited by 93 · see citing works

Global Gene Expression Analysis of Murine Limb Development

Taher, L., Collette, N. M., Murugesh, D. K., Maxwell, E. K., Ovcharenko, I., & Loots, G. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028358 · Cited by 92 · see citing works

A Single Pitx1 Binding Site Is Essential for Activity of the LHβ Promoter in Transgenic Mice

Quirk, C. C., Lozada, K. L., Keri, R. A., & Nilson, J. H. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.5.0628 · Cited by 88 · see citing works

Familial Isolated Clubfoot Is Associated with Recurrent Chromosome 17q23.1q23.2 Microduplications Containing TBX4

Alvarado, D. M., Aferol, H., McCall, K., Huang, J. B., Techy, M., Buchan, J. G., Cady, J., Gonzales, P. R., Dobbs, M. B., & Gurnett, C. A. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.06.010 · Cited by 85 · see citing works

Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development

Krause, A., Zacharias, W. J., Camarata, T., Linkhart, B., Law, E. C., Lischke, A., Miljan, E., & Simon, H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.05.024 · Cited by 85 · see citing works

Tbx4is not required for hindlimb identity or post-bud hindlimb outgrowth

Naiche, L. A., & Papaioannou, V. E. (2006) · Development · doi:10.1242/dev.02712 · Cited by 84 · see citing works

Pitx1 haploinsufficiency causes clubfoot in humans and a clubfoot-like phenotype in mice

Alvarado, D. M., McCall, K., Aferol, H., Silva, M. J., Garbow, J. R., Spees, W. M., Patel, T. K., Siegel, M. J., Dobbs, M. B., & Gurnett, C. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr313 · Cited by 83 · see citing works

Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

Domyan, E. T., Kronenberg, Z. N., Infante, C. R., Vickrey, A. I., Stringham, S. A., Bruders, R., Guernsey, M. W., Park, S., Payne, J. A., Beckstead, R. B., et al. (2016) · eLife · doi:10.7554/elife.12115 · Cited by 83 · see citing works

Testing the effects of FSHD candidate gene expression in vertebrate muscle development.

Wuebbles, R. D., Long, S. W., Hanel, M. L., & Jones, P. L. (2010) · PubMed Central · Cited by 82 · see citing works

Finger or toe: the molecular basis of limb identity

Logan, M. P. O. (2003) · Development · doi:10.1242/dev.00956 · Cited by 81 · see citing works

The contribution of chicken embryology to the understanding of vertebrate limb development

Tickle, C. A. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.05.015 · Cited by 80 · see citing works

The genome of the Gulf pipefish enables understanding of evolutionary innovations

Small, C. M., Bassham, S., Catchen, J., Amores, A., Fuiten, A. M., Brown, R. S., Jones, A. G., & Cresko, W. A. (2016) · Genome biology · doi:10.1186/s13059-016-1126-6 · Cited by 78 · see citing works

Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma

Lord, R. V., Brabender, J., Wickramasinghe, K. S., DeMeester, S. R., Hölscher, A. H., Schneider, P. M., Danenberg, P. V., & DeMeester, T. R. (2005) · Surgery · doi:10.1016/j.surg.2005.05.007 · Cited by 77 · see citing works

Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart

Li, Q., Liu, J., & Bodmer, R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.013 · Cited by 76 · see citing works

A Comparative Molecular Analysis of Developing Mouse Forelimbs and Hindlimbs Using Serial Analysis of Gene Expression (SAGE)Preprint

Margulies, E. H., Kardia, S. L. R., & Innis, J. W. (2001) · Genome Research · doi:10.1101/gr.192601 · Cited by 76 · see citing works

The molecular control of upper extremity development: Implications for congenital hand anomalies

Daluiski, A., Yi, S. E., & Lyons, K. M. (2001) · The Journal Of Hand Surgery · doi:10.1053/jhsu.2001.9419 · Cited by 75 · see citing works

Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback

Cole, N. J., Tanaka, M., Prescott, A., & Tickle, C. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.039 · Cited by 74 · see citing works

Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy

Greco, A., Goossens, R., van Engelen, B. G. M., & van der Maarel, S. M. (2020) · Clinical Genetics · doi:10.1111/cge.13726 · Cited by 74 · see citing works

Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes

Tanaka, M., Hale, L. A., Amores, A., Yan, Y., Cresko, W. A., Suzuki, T., & Postlethwait, J. H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.016 · Cited by 74 · see citing works

cis‐regulatory mutations are a genetic cause of human limb malformations

VanderMeer, J. E., & Ahituv, N. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22535 · Cited by 73 · see citing works

Pelvic fins in teleosts: structure, function and evolution

Yamanoue, Y., Setiamarga, D. H. E., & Matsuura, K. (2010) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2010.02674.x · Cited by 74 · see citing works

Human syndromes with congenital patellar anomalies and the underlying gene defects

Bongers, E. M., van Kampen, A., van Bokhoven, H., & Knoers, N. V. A. M. (2005) · Clinical Genetics · doi:10.1111/j.1399-0004.2005.00508.x · Cited by 73 · see citing works

Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos

Itou, J., Kawakami, H., Quach, T., Osterwalder, M., Evans, S. Μ., Zeller, R., & Kawakami, Y. (2012) · Development · doi:10.1242/dev.073056 · Cited by 73 · see citing works

Genetics of clubfoot; recent progress and future perspectives

Basit, S., & Khoshhal, K. I. (2017) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2017.09.006 · Cited by 72 · see citing works

Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice

Bravard, A., Bonnard, C., Durand, A., Chauvin, M., Favier, R. J. M., Vidal, H., & Rieusset, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00455.2010 · Cited by 72 · see citing works

Pigeonetics takes flight: Evolution, development, and genetics of intraspecific variation

Domyan, E. T., & Shapiro, M. D. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.008 · Cited by 67 · see citing works

Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes

Mitsiadis, T. A., & Drouin, J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.055 · Cited by 68 · see citing works

Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion

Wu, P., Yan, J., Lai, Y., Ng, C. S., Li, A., Jiang, X., Elsey, R. M., Widelitz, R. B., Bajpai, R., Li, W., et al. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx295 · Cited by 68 · see citing works

FGF and genes encoding transcription factors in early limb specification

Isaac, A., Cohn, M. J., Ashby, P. R., Ataliotis, P., Spicer, D. B., Cooke, J., & Tickle, C. A. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00261-6 · Cited by 67 · see citing works

Functional conservation of the wingless–engrailed interaction as shown by a widely applicable baculovirus misexpression system

Oppenheimer, D. I., MacNicol, A. M., & Patel, N. H. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80050-0 · Cited by 64 · see citing works

Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control

Duboc, V., & Logan, M. P. O. (2011) · Development · doi:10.1242/dev.074153 · Cited by 62 · see citing works

A Combination of Activation and Repression by a Colinear Hox Code Controls Forelimb-Restricted Expression of Tbx5 and Reveals Hox Protein Specificity

Nishimoto, S., Minguillón, C., Wood, S., & Logan, M. P. O. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004245 · Cited by 61 · see citing works

A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

Long, S. W., Ooi, J. Y. Y., Yau, P. M., & Jones, P. L. (2010) · Bioscience Reports · doi:10.1042/bsr20100124 · Cited by 60 · see citing works

Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements

Infante, C. R., Park, S., Mihala, A. G., Kingsley, D. M., & Menke, D. B. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.017 · Cited by 61 · see citing works

A Perspective on Micro-Evo-Devo: Progress and Potential

Nunes, M. D. S., Arif, S., Schlötterer, C., & McGregor, A. P. (2013) · Genetics · doi:10.1534/genetics.113.156463 · Cited by 57 · see citing works

Pitx2 in Embryonic and Adult Myogenesis

Hernández‐Torres, F., Rodríguez-Outeiriño, L., Franco, D., & Aránega, A. E. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00046 · Cited by 60 · see citing works

Different Regulation of T-Box Genes Tbx4 and Tbx5 during Limb Development and Limb Regeneration

Khan, P., Linkhart, B., & Simon, H. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0801 · Cited by 58 · see citing works

Divergent transcriptional activities determine limb identity

Ouimette, J., Lavertu-Jolin, M., L’honoré, A., Gifuni, A. J., & Drouin, J. (2010) · Nature Communications · doi:10.1038/ncomms1036 · Cited by 56 · see citing works

Selector Genes and Limb Identity in Arthropods and Vertebrates

Weatherbee, S. D., & Carroll, S. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80737-0 · Cited by 56 · see citing works

Regulation of Mandibular Growth and Morphogenesis

Mina, M. (2001) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411010120040101 · Cited by 55 · see citing works

Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs

Horton, A. C., Mahadevan, N. R., Minguillón, C., Osoegawa, K., Rokhsar, D. S., Ruvinsky, I., de Jong, P. J., Logan, M. P. O., & Gibson‐Brown, J. J. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0249-5 · Cited by 55 · see citing works

Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice

Pandey, S. N., Cabotage, J., Shi, R., Dixit, M., Sutherland, M., Liu, J., Muger, S., Harper, S. Q., Nagaraju, K., & Chen, Y. (2012) · Biology Open · doi:10.1242/bio.20121305 · Cited by 54 · see citing works

Role of Pitx1 Upstream of Tbx4 in SpeciÞcation of Hindlimb Identity

Logan, M., & Tabin, C. J. (2014)

Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb

DeLaurier, A., Schweitzer, R., & Logan, M. P. O. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.055 · Cited by 159 · see citing works

Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control

Duboc, V., & Logan, M. P. O. (2011) · Development · doi:10.1242/dev.074153 · Cited by 62 · see citing works

Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

Szeto, D. P., Rodriguez-Esteban, C., Ryan, A. K., O'Connell, S. M., Liu, F., Kioussi, C., Gleiberman, A. S., Izpisua-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.4.484 · Cited by 426 · see citing works

Pitx1andPitx2are required for development of hindlimb buds

Marcil, A., Dumontier, É., Chamberland, M., Camper, S. A., & Drouin, J. (2002) · Development · doi:10.1242/dev.00192 · Cited by 177 · see citing works