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Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression.
Open accessAbstract
The influx of calcium into the postsynaptic neuron is likely to be an important event in memory formation. Among the mechanisms that nerve cells may use to alter the time course or size of a spike of intracellular calcium are cytosolic calcium binding or "buffering" proteins. To consider the role in memory formation of one of these proteins, calbindin D28K, which is abundant in many neurons, including the CA1 pyramidal cells of the hippocampus, transgenic mice deficient in calbindin D28K have been created. These mice show selective impairments in spatial learning paradigms and fail to maintain long-term potentiation. These results suggest a role for calbindin D28K protein in temporally extending a neuronal calcium signal, allowing the activation of calcium-dependent intracellular signaling pathways underlying memory function.
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Cites
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
Adler, E., Augustine, G., Duffy, S., & Charlton, M. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-06-01496.1991 · Cited by 624
Cited by
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
Lu, Y.-M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R., Wojtowicz, J. M., & Roder, J. C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05196.1997 · Cited by 634
HIV and antiretroviral therapy in the brain: neuronal injury and repair
Ellis, R., Langford, D., & Masliah, E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2040 · Cited by 517
Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402
Schwaller, B., Meyer, M., & Schiffmann, S. (2002) · The Cerebellum · doi:10.1080/147342202320883551 · Cited by 386
Metadata
- Authors
- Molinari, S., Battini, R., Ferrari, S., Pozzi, L., Killcross, A. S., Robbins, T. W., Jouvenceau, A., Billard, J. M., Dutar, P., Lamour, Y., Baker, W. A., Cox, H., & Emson, P. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-07-23
- Volume
- 93
- Issue
- 15
- Pages
- 8028-8033
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992173856
- Cited by
- 160
- References
- 2
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Molinari, S., Battini, R., Ferrari, S., Pozzi, L., Killcross, A. S., Robbins, T. W., Jouvenceau, A., Billard, J. M., Dutar, P., Lamour, Y., Baker, W. A., Cox, H., & Emson, P. C. (1996). Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.15.8028
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