The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CAX1, an H+/Ca2+ antiporter from Arabidopsis.
Open accessAbstract
Reestablishment of the resting state after stimulus-coupled elevations of cytosolic-free Ca2+ requires the rapid removal of Ca2+ from the cytosol of plant cells. Here we describe the isolation of two genes, CAX1 and CAX2, from Arabidopsis thaliana that suppress a mutant of Saccharomyces cerevisiae that has a defect in vacuolar Ca2+ accumulation. Both genes encode polypeptides showing sequence similarities to microbial H+/Ca2+ antiporters. Experiments on vacuolar membrane-enriched vesicles isolated from yeast expressing CAX1 or CAX2 demonstrate that these genes encode high efficiency and low efficiency H+/Ca2+ exchangers, respectively. The properties of the CAX1 gene product indicate that it is the high capacity transporter responsible for maintaining low cytosolic-free Ca2+ concentrations in plant cells by catalyzing pH gradient-energized vacuolar Ca2+ accumulation.
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Cites
Cunningham, K. W., & Fink, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2226 · Cited by 431
Self-citation
Cited by
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Protein Phylogenetic Analysis of Ca2+/cation Antiporters and Insights into their Evolution in Plants
Emery, L., Whelan, S., Hirschi, K. D., & Pittman, J. K. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00001 · Cited by 929
Self-citationDrought- and salt-tolerant plants result from overexpression of the AVP1 H + -pump
Gaxiola, R. A., Li, J., Undurraga, S., Dang, L. M., Allen, G. J., Alper, S. L., & Fink, G. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191389398 · Cited by 746
Self-citationEvolutionary Ecology of Plant Adaptation to Serpentine Soils
Brady, K. U., Kruckeberg, A. R., & Bradshaw Jr., H. D. (2005) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev.ecolsys.35.021103.105730 · Cited by 733
Wang, R., Guegler, K., LaBrie, S. T., & Crawford, N. M. (2000) · The Plant Cell · doi:10.1105/tpc.12.8.1491 · Cited by 578
Metadata
- Authors
- Hirschi, K. D., Zhen, R. G., Cunningham, K. W., Rea, P. A., & Fink, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-08-06
- Volume
- 93
- Issue
- 16
- Pages
- 8782-8786
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2008204889
- Cited by
- 294
- References
- 1
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Hirschi, K. D., Zhen, R. G., Cunningham, K. W., Rea, P. A., & Fink, G. R. (1996). CAX1, an H+/Ca2+ antiporter from Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.16.8782
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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