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Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Open accessAbstract
We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
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Cited by
Double muscling in cattle due to mutations in the myostatin gene
McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039
Hanrahan, J. P., Gregan, S. M., Mulsant, P., Mullen, M., Davis, G. H., Powell, R., & Galloway, S. M. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.023093 · Cited by 855
REGULATION OF MUSCLE MASS BY MYOSTATIN
Lee, S.-J. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.012103.135836 · Cited by 819
The transforming growth factor-β superfamily of receptors
de Caestecker, M. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.004 · Cited by 464
Szkudlinski, M. W., Fremont, V., Ronin, C., & Weintraub, B. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00031.2001 · Cited by 458
Metadata
- Authors
- Griffith, D. L., Keck, P. C., Sampath, T. K., Rueger, D. C., & Carlson, W. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-01-23
- Volume
- 93
- Issue
- 2
- Pages
- 878-883
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060165686
- Cited by
- 299
- References
- 0
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Griffith, D. L., Keck, P. C., Sampath, T. K., Rueger, D. C., & Carlson, W. D. (1996). Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.2.878
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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