The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)1
Open accessAbstract
Belclare and Cambridge are prolific sheep breeds, the origins of which involved selecting ewes with exceptionally high litter size records from commercial flocks. The variation in ovulation rate in both breeds is consistent with segregation of a gene (or genes) with a large effect on this trait. Sterile ewes, due to a failure of normal ovarian follicle development, occur in both breeds. New naturally occurring mutations in genes for the oocyte-derived growth factors growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are described. These mutations are associated with increased ovulation rate in heterozygous carriers and sterility in homozygous carriers in both breeds. This is the first time that a mutation in the gene for GDF9 has been found that causes increased ovulation rate and infertility in a manner similar to inactivating mutations in BMP15, and shows that GDF9 is essential for normal folliculogenesis in sheep. Furthermore, it is shown, for the first time in any species, that individuals with mutations in both GDF9 and BMP15 have a greater ovulation rate than sheep with either of the mutations separately.
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Cites
Growth differentiation factor-9 is required during early ovarian folliculogenesis
Dong, J., Albertini, D. F., Nishimori, K., Kumar, T. R., Lu, N., & Matzuk, M. M. (1996) · Nature · doi:10.1038/383531a0 · Cited by 1,646
Galloway, S. M., McNatty, K. P., Cambridge, L. M., Laitinen, M. P. E., Juengel, J. L., Jokiranta, T. S., McLaren, R. J., Luiro, K., Dodds, K. G., Montgomery, G. W., et al. (2000) · Nature Genetics · doi:10.1038/77033 · Cited by 1,097
Self-citationYan, C., Wang, P., DeMayo, J. L., DeMayo, F. J., Elvin, J. A., Cariño, C., Prasad, S. V., Skinner, S. M., Dunbar, B. S., Dube, J. L., et al. (2001) · Molecular Endocrinology · doi:10.1210/me.15.6.854 · Cited by 835
Wilson, T., Wu, X.-Y., Juengel, J. L., Ross, I. K., Lumsden, J. M., Lord, E. A., Dodds, K. G., Walling, G. A., McEwan, J. C., O’Connell, A. R., et al. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.4.1225 · Cited by 548
The Bone Morphogenetic Protein 15 Gene Is X-Linked and Expressed in Oocytes
Dube, J. L., Wang, P., Elvin, J. A., Lyons, K. M., Celeste, A. J., & Matzuk, M. M. (1998) · Molecular Endocrinology · doi:10.1210/me.12.12.1809 · Cited by 525
Mulsant, P., Lecerf, F., Fabre, S., Schibler, L., Monget, P., Lanneluc, I., Pisselet, C., Riquet, J., Monniaux, D., Callebaut, I., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091577598 · Cited by 492
Self-citationOocyte-specific expression of growth/differentiation factor-9
McGrath, S. A. (1995) · Molecular Endocrinology · doi:10.1210/me.9.1.131 · Cited by 490
Juengel, J. L., Hudson, N. L., Heath, D. A., Smith, P., Reader, K. L., Lawrence, S. B., O’Connell, A. R., Laitinen, M. P. E., Cranfield, M., Groome, N. P., et al. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.102.007146 · Cited by 329
Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells
Moore, R. K., Otsuka, F., & Shimasaki, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207362200 · Cited by 326
Crystal structure of the BMP-2–BRIA ectodomain complex
Kirsch, T., Sebald, W., & Dreyer, M. K. (2000) · Nature Structural Biology · doi:10.1038/75903 · Cited by 319
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Harnessing genomic information for livestock improvement
Georges, M., Charlier, C., & Hayes, B. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0082-2 · Cited by 384
Juengel, J. L., & McNatty, K. P. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmh061 · Cited by 373
Purfield, D. C., McParland, S., Wall, E., & Berry, D. P. (2017) · PLOS ONE · doi:10.1371/journal.pone.0176780 · Cited by 308
The search for genes contributing to endometriosis risk
Montgomery, G. W., Nyholt, D. R., Zhao, Z. Z., Treloar, S. A., Painter, J. N., Missmer, S. A., Kennedy, S. H., & Zondervan, K. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn016 · Cited by 211
Metadata
- Authors
- Hanrahan, J. P., Gregan, S. M., Mulsant, P., Mullen, M., Davis, G. H., Powell, R., & Galloway, S. M.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-04-01
- Volume
- 70
- Issue
- 4
- Pages
- 900-909
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2129012279
- Cited by
- 855
- References
- 27
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)1. https://app.cochat.ai/papers/10.1095/biolreprod.103.023093
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- Hanrahan, J. P., Gregan, S. M., Mulsant, P., Mullen, M., Davis, G. H., Powell, R., & Galloway, S. M. (2004). Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.103.023093
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