The transforming growth factor-β superfamily of receptors

de Caestecker, Mark

doi:10.1016/j.cytogfr.2003.10.004

Cited by 464TGF-β signaling in diseasesReceptor Mechanisms and SignalingLiver physiology and pathology

The transforming growth factor-β superfamily of receptors

de Caestecker, Mark·2004·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2003.10.004

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Abstract

The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells.

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A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
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Authors: de Caestecker, M.
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2004-02
Volume: 15
Issue: 1
Pages: 1-11
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2003.10.004
OpenAlex: W2084954119
Cited by: 464
References: 161
Citations by year: 2026: 5 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 14 · 2021: 16 · 2020: 19 · 2019: 20 · 2018: 23 · 2017: 17 · 2016: 14 · 2015: 11 · 2014: 21 · 2013: 23 · 2012: 25
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: TGF-beta superfamily, TGF-beta receptor, type I receptor, type II receptor, serine/threonine kinase receptors, receptor activation, ligand-receptor interactions, mammalian cells
MeSH terms: Animals, Gene Expression Regulation, Multigene Family, Humans, Ligands, Models, Biological, Protein Binding, Endosomes, Signal Transduction, Receptors, Transforming Growth Factor beta, Activins

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The transforming growth factor-β superfamily of receptors

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